A novel 2D hydrogenated-silicon nanosheet (H-Si NSs) is integrated and functionalized into a β-tricalcium phosphate scaffold (H-Si TCP) for immuno-bone remodeling in our study. H-Si NSs has great ROS-responsive, immunoregulatory, and osteo-promotive property and H-Si TCP can provide sufficient ingredients and greatly improve bone regeneration step by step through osteoimmunomodulation-guided biodegradation in vivo.
An ideal implant needs to have the ability to coordinate the foreign body response and tissue regeneration. Here, Hydrogenated-silicon nanosheets (H-Si NSs) with favorable biodegradability are integrated and functionalized into a β-tricalcium phosphate scaffold (H-Si TCP) for bone defect healing. H-Si TCP can greatly improve bone regeneration through osteoimmunomodulation-guided biodegradation in vivo. The spatiotemporal regulation of degradation products replenishes sufficient nutrients step by step for the entire process of bone repair. Extracellular and intracellular reactive oxygen species (ROS) are first downregulated by reaction with H-Si NSs, followed by marked M2 polarization, remodeling the micro-environment timely for immune-bone regeneration. The release of primary reaction products awakened bone marrow mesenchymal stem cells (BMSCs), which are converted into osteoblasts anchored on scaffolds. Subsequently, biomineralization is promoted by the final degradation products. The intrinsic ROS-responsive, immunoregulatory, and osteo-promotive capability of 2D H-Si NSs makes such composite H-Si TCP scaffold a highly potential alternative for the treatment of critical bone defect.
Zixuan Lin†, Zhixin Chen†, Yiwei Chen, Nan Yang, Jianlin Shi, Zhongmin Tang, Changqing Zhang*, Han Lin*, Junhui Yin*
How to cite:
Z. Lin, Z. Chen, Y. Chen, N. Yang, J. Shi, Z. Tang, C. Zhang, H. Lin, J. Yin, Exploration 2023, 3, 20220149.