Multifunctional and reusable PHC wound dressing was designed for accelerating movable wound healing process. With alternated NIR light irradiation, PHC can produce abundant heat and ROS for bacteria inactivation due to its photothermal and pyroelectric property. With the frequent movement of movable wound, PHC can effectively promote cell migration and proliferation due to its piezoelectric property.
Abstract:
Wound healing in movable parts poses challenges owing to frequent activities, leading to delayed recovery and heightened susceptibility to bacterial infections and inflammation. Although hydrogel-based dressings have been explored, their therapeutic effectiveness is limited by poor resistance to stimuli and low mechanical strength. Here, we present a novel multifunctional PHC bandage that prevents bacterial infection and capitalizes on the inherent mobility of the affected area to expedite the wound-healing process. A PHC bandage was fabricated by incorporating photothermal copper bismuth sulfide (Cu3BiS3) nanomaterials into piezoelectric and pyroelectric polyvinylidene fluoride (PVDF). Upon exposure to alternating near-infrared light, the embedded Cu3BiS3 generated localized heat, activated PVDF, and induced the production of abundant reactive oxygen species for bacterial inactivation. Furthermore, continuous movement of the wound area triggers the PVDF to generate a sustained electrical field, promoting cell migration and proliferation to facilitate wound healing. The wound healing rate of PHC was 13.17 ± 2.09% higher than medical gauze. The robust encapsulation of PVDF ensured secure containment of the loaded Cu3BiS3 nanoparticles, improving the biocompatibility and sustainable utilization of this innovative wound dressing. This innovative design offers a promising and effective solution for improving wound healing in movable parts, potentially revolutionizing wound care technology.
Author list:
Liqi Wei†, Xin Liu†, Yuanqiang Li, Yu Han, Yiping Ren, Tianshu Zou, Pengcheng Yu, Yining Chen, Biao Zhang, Zixuan Wang, Jingyi Jiang, Yumi Kim, Rui Chen*, Yan Cheng*, Hongxia Ma*
How to cite:
L. Wei, X. Liu, Y. Li, Y. Han, Y. Ren, T. Zou, P. Yu, Y. Chen, B. Zhang, Z. Wang, J. Jiang, Y. Kim, R. Chen, Y. Cheng, H. Ma, Exploration 2025, 20230176.
https://doi.org/10.1002/EXP.20230176