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Mechanistic Illustration of the facet modulated Ru(bpy)32+ cathodic/anodic ECL system. O2 molecules undergo ORR at the cathode, while H2O molecules undergo OER at the anode on different catalyst facets. Ni/NG-1 exhibits high OER but low ORR activity, generating radicals that react with Ru(bpy)32+ to enhance cathodic ECL. In contrast, Ni/NG-2 shows high ORR but low OER activity, thus …

Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy)32+ Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER Read More »

Through ab initio molecular dynamics theoretical calculations, we reveal that incorporation of excess halogen at sulfur site (4d) accelerates inter-cage jumps of Li+ with a low migration energy barrier. Subsequently, iodine-rich Li6−xPS5−xClIx (0 ≤ x ≤ 0.2) electrolytes with high ionic conductivity are successfully synthesized. Therefore, all-solid-state batteries with LPSC-0.1LiI electrolyte deliver excellent electrochemical properties. Abstract: Although iodine (I) …

Elucidating and Optimizing I Occupation in Lithium Argyrodite Solid Electrolytes for Advanced All-Solid-State Li Metal Batteries Read More »

Protecting neuronal mitochondria by eliminating the mitochondrial ROS (mtROS) storm is crucial to abrogate the neuronal damage cascade of ischemic stroke ischemia reperfusion (ISIR), which is a long-standing challenge in the field of ischemic stroke (IS). Existing blood-brain barrier (BBB) penetration methods are usually unable to distinguish between healthy brain tissue and cerebral infarction tissue, …

Specifically Breaking Through the Injured Blood-Brain Barrier With Tannic Acid-Based Nanomedicine for Ischemic Stroke Ischemia Reperfusion Treatment Read More »

Multidrug-resistant Klebsiella pneumoniae poses a significant threat as a nosocomial pathogen, with no current licensed vaccines available. This study used a mutant E. coli strain expressing exogenous polysaccharides (from K. pneumoniae) to establish glycoengineered generalized modules for membrane antigens (geGMMA) vaccine platform, which demonstrated potent humoral immune responses and protection against K. pneumoniae infections. This approach could lead to safer large-scale vaccine …

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA) Read More »

The inhibition of joint synovial inflammation, caused by poor oxygen (O2) supply and excessive reactive oxygen species (ROS) generation, is an important treatment strategy for rheumatoid arthritis (RA). A targeted ruthenium-based anti-inflammatory nanosystem (RuFOMs-FA) based of ultra-small ruthenium clusters-loaded F127-organosilica micelles with folic acid modification is designed and developed. A two-stage macrophage regulatory mechanism involving …

Targeted Ruthenium-Based Anti-Inflammatory Nanoagent for Enhanced Rheumatoid Arthritis Treatment Read More »

Immunomodulatory nanozymes enable in situ macrophages engineering and orchestrate systemic innate-adaptive immune response to eradicate intracellular bacteria and rescue immunoparalysis for treating multidrug-resistant bacterial sepsis. Abstract: Sepsis and their sequelae are the leading causes of death in intensive care units, with limited therapeutic options. Immunoparalysis plays a vital role in the pathophysiological progression of sepsis, …

Immunomodulatory Nanozymes Eradicate Intracellular Infections and Rescue Immunoparalysis for Treating Multidrug-Resistant Bacterial Sepsis Read More »

Inspired by the cactus branch, this work proposed an asymmetrical pleated structure textile embedded with a unidirectional water transport channel. Water repellency, water collection, and directional water transport ability are assembled into one unified system by means of the asymmetrical pleated structure, which is expected to enable efficient moisture regulation for humans. Abstract: Asymmetrical pleated …

Bioinspired Asymmetrical Pleated Textile With Unidirectional Transport Channel for Personal Moisture and Thermal Management Read More »