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Recent progress in quantitative analysis of self-assembled peptides

Self-assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. This review summarizes the techniques for quantitative analysis, including imaging-based quantitative techniques, chromatographic technique, and computational approach. These techniques can facilitate the investigation of the structure, properties, biomedical applications, and even supramolecular assembly processes of self-assembled peptides. The perspective …

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Telemedicine-medical “snack community”-PHS ecosystem: Insights into the double-edged sword role of telemedicine in clinical practice and medical education during the COVID-19 pandemic and beyond

1. “Telemedicine-medical ‘snack community’-PHS ecosystem” indicates the plight during the transformation of traditional culture into sack culture in modern society.2. The supports of regulations made by government and the third-party supervision are prerequisite for medical education and fitness of medical practitioners and patients.3. Constructions of infrastructure, medical education and expertise of medical workers are far …

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Bioimaging and prospects of night pearls-based persistence phosphors in cancer diagnostics

This review is directed at the bioimaging of persistent phosphors. Typical synthetic methods such as the high-temperature solid state, thermal decomposition, hydrothermal/solvothermal, and template methods are proposed. The luminescence mechanisms of persistent phosphors are discussed and effective matrixes including galliumate, germanium, aluminate, and fluoride is explored. Finally, persistence phosphors have the potential to improve the …

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Unveiling the importance of the interface in nanocomposite cathodes for proton-conducting solid oxide fuel cells

The interface of nanocomposite cathode plays a critical role in the performance of proton-conducting solid oxide fuel cells (H-SOFCs), which has been demonstrated by atomic level studies with the first-principles calculations, nanoscale studies by using the pulsed laser deposition method and the prototype fuel cell studies. The resultant BaZr0.4Co0.6O3 cathode leads to a record-breaking power …

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Endoperoxide-enhanced self-assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy

To overcome the pharmacological limitations of artemisinin in cancer therapy, the novel pH-responsive artesunate (ARS)-4-hydroxybenzoyl hydrazide (HBZ)-5-amino levulinic acid (ALA) nanoparticles (AHA NPs) with self-supplied capacity of reactive oxygen species (ROS) were reported to realize excellent chemotherapy and chemodynamic therapy (CDT). Abstract: Prodrug-based self-assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant …

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Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery

Using pig cornea as a target, aptamers were selected using the tissue-SELEX method. By attaching the aptamers to liposomes loaded with cyclosporin A, improved treatment of dry eye disease was achieved in vitro and in vivo. Abstract: Cornea is the major barrier to drug delivery to the eye, which results in low bioavailability and poor …

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Oxygen-carrying semiconducting polymer nanoprodrugs induce sono-pyroptosis for deep-tissue tumor treatment

An oxygen-carrying semiconducting polymer nanoprodrug is reported to combine amplified sonodynamic therapy with pyroptosis for deep tumor treatment. The nanoprodrug delivers oxygen to relieve tumor hypoxia microenvironment and thus mediate prodrug activation for pyroptosis. This nanoprodrug-based treatment greatly inhibits the growth of 2-cm chicken breast tissue-covered deep tumors and suppresses tumor metastasis. Abstract: Sonodynamic therapy …

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Jellyfish stings-induced cardiac failure was ameliorated through AAG-mediated glycogen-driven ATP production

Single cell sequencing revealed AAG, an energy regulatory protein targeting to glycogen, was highly expressed in jellyfish stings-induced CF patients. We postulated AAG could increase glycogen metabolism, protecting against jellyfish stings-induced CF. Intriguingly, AAG improved cardiac function and metabolic adaptation by glycogen-driven ATP production, shifting mitochondrial / glycolytic ATP production towards glycolysis. Sorted by single-cell …

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Bioprinted research models of urological malignancy

In this review, a series of bioprinted research models are presented for the fundamental research of urological malignancies. This review summarizes and discusses five aspects, including bioprinting technology, polymer-based inks, collection of seeding cells, culturing of cancer models, and the applications for biomedical research. Moreover, several current challenges and future directions are prospected and highlighted. …

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Stimuli-responsive linkers and their application in molecular imaging

Stimuli-responsive linkers are appealing tools to improve the specificity, sensitivity, and efficacy of molecular imaging. In this review, the recent examples and progress toward the development of stimuli-responsive linkers and their application in molecular imaging are systematically summarized, highlighting the potential of these linkers in the design of activatable molecular imaging probes. Abstract: Molecular imaging …

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