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Gd2O3/b-TiO2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy

Low photoconversion efficiency and limited tissue penetration are the major barriers for photothermal therapy (PTT) agent application. Here, an efficient organic/inorganic dual-PTT agent guided by MRI was proposed. It is proved the oxygen vacancy band narrowed its band gap that led to NIR-II region absorb. Furthermore, the defect energy level trapping carrier and conjugate synergistic …

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Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

Clinically approved indocyanine green (ICG) is utilized to develop simple prodrug nanoformulations. The ICG-driven assembly strategy endows paclitaxel prodrugs improved assembled behavior and enhanced colloidal stability, and the developed nanoparticles possess tumor-specific imaging and chemotherapy with in vivo therapeutic feedback. Abstract: Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. …

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Mechanisms for self-templating design of micro/nanostructures toward efficient energy storage

The micro/nanostructure design via self-templating method offers a viable way to significantly improve the electrochemical performances of functional materials. This review introduces five main self-templating mechanisms and compares the merits of different micro/nanostructures for energy storage. Furthermore, a summary of current challenges and the prospect of self-templating strategy for constructing high-performance electrode materials are also …

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Direct chemical editing of Gram-positive bacterial cell walls via an enzyme-catalyzed oxidative coupling reaction

This work describes a mild and efficient enzyme-catalyzed chemical reaction for the selective modification of Gram-positive bacterial cell walls. The as-designed technique can serve as a universal platform to functionalize the surfaces of live bacterial cells with diverse responsive materials, including small-molecule fluorescent dyes, horseradish peroxidase, and magnetic nanoparticles. Abstract: Chemically manipulating bacterial surface structures, …

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Recent advances in self-powered and flexible UVC photodetectors

This review introduced and discussed strategies for fabricating self-powered UVC photodetectors in terms of the device structure, photoactive material, and flexible substrates. Based on the summary of previous works, we presented a brief outlook of challenges and future strategies for deep-UVC photodetectors. Abstract: Ultraviolet-C (UVC) radiation is employed in various applications, including irreplaceable applications in …

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Therapeutic gas-releasing nanomedicines with controlled release: Advances and perspectives

This review takes a critical look at four key gasotransmitters (CO, NO, H2S and SO2) with their incorporation into prodrugs known as gas-releasing molecule. Different nanosystems and their mediatory roles for efficient shuttling, targeting and cleavage of therapeutic gases and the responsiveness to typical internal and external stimuli for gas release from prodrugs have been …

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Role of bioaerosol in virus transmission and material-based countermeasures

Virus dissemination through droplets or aerosols is a predominant transmission mode of respiratory infections. This review summarizes direct and indirect mechanisms of aerosol generation with an emphasis on infection risks presented by the resuspension of settled droplets. Material-based approaches, including nanotechnology, to contain bioaerosol-mediated virus transmission are highlighted in this review. Abstract: Respiratory pathogens transmit …

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Recent applications of immunomodulatory biomaterials for disease immunotherapy

Understanding the immunomodulatory functions of biomaterials themselves is critical for developing safe and effective immunotherapeutic platforms. This review summarizes some representative biomaterials with immunomodulatory functions discovered in recent years and their applications in therapy for inflammation, tumor, and autoimmune diseases, and discusses the challenges for the future development of biomaterials. Abstract: Immunotherapy is used to …

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A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection

A dynamic covalent polymeric antimicrobial, based on phenylboronic acid-installed micellar nanocarriers incorporating vancomycin and curcumin, was developed to overcome drug-resistant bacterial infections. Compared with monotherapy, this antimicrobial displayed more significant eradication of drug-resistant bacteria in vitro and in vivo. This work could become a universal platform to combat the ever-threatening drug-resistant infectious diseases. Abstract: Increasing …

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Functional nucleic acid engineered double-barreled nanopores for measuring sodium to potassium ratio at single-cell level

Functional nucleic acid engineered double-barreled nanopores were designed and applied for measuring Na/K ratio (RNa/K) at single-cell level. The applicability of this nanotool is validated by practical probing intracellular RNa/K during the drug-induced primary stage of apoptotic volume decrease. Especially, the RNa/K has been shown by our nanotool to be different in cell lines with different metastatic …

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