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Burst of hopping trafficking correlated reversible dynamic interactions between lipid droplets and mitochondria under starvation

Article, Research Article / By

The reversible interactions between LDs and mitochondria are tracked in real-time using a robust LDs-specific fluorescent probe (LDs-Tags). LDs exhibit active transport and are inclined to repeatedly search for a suitable contact site on the mitochondrial membrane under nutrient starvation. Intermittent larger jumps are observed between clustered small steps during this process. Abstract: Dynamic membrane …

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Tumor microenvironment-responsive delivery nanosystems reverse immunosuppression for enhanced CO gas/immunotherapy

Article, Research Article / By

TME-responsive delivery nanosystems with rough surfaces (M-RMH) are proposed to enhance CO gas/immunotherapy through immune activation and immunosuppression regulation simultaneously. After the combination with aPD-L1-mediated checkpoint blockade therapy, robust antitumor immune responses are found to inhibit both primary and distant tumors. Abstract: Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis …

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Physicochemical understanding of biomineralization by molecular vibrational spectroscopy: From mechanism to nature

Article, Review Article / By

An overview of the biomineralization process from the perspective of molecular vibrational spectroscopy, including the physicochemical properties of biomineralized tissues, from physiological to applied mineralization. Indeed, the clearly defined physicochemical properties of mineral crystals could pave the way for studies on the mechanisms and applications. Abstract: The process and mechanism of biomineralization and relevant physicochemical …

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Achievements and challenges of copper-based single-atom catalysts for the reduction of carbon dioxide to C2+ products

Article, Perspective / By

The design strategies of single-atom copper catalysts are briefly summarized and the key factor for their application in industrially electrochemical conversion of CO2 into C2 and C2+ products are pointed out. Abstract: Copper is the only metal that can convert CO2 into C2 and C2+ in electrocatalytic carbon dioxide reduction (CO2RR). However, the Faraday efficiency of CO2 conversion …

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Engineered nanodrug targeting oxidative stress for treatment of acute kidney injury

Article, Review Article / By

Engineered nanoparticles targeting oxidative stress have shown promising perspectives in treating acute kidney injury (AKI). By examining the challenges, advancements, and limitations of different studies in this field, this review fills a significant knowledge gap. In addition, it offers valuable insights for future research on engineering nanoparticles to address AKI. Abstract: Acute kidney injury (AKI) …

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Artificial intelligence in breast imaging: Current situation and clinical challenges

Article, Review Article / By

This paper provides an overview of the current state of artificial intelligence (AI) in breast imaging, encompassing breast imaging databases, deep learning algorithms, and clinical research. The authors additionally discuss the progress of breast imaging AI through the lens of National Natural Science Foundation of China project proposals. Finally, the authors address the perspectives and …

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Scientific issues of zinc-bromine flow batteries and mitigation strategies

Article, Review Article / By

Zinc-bromine flow batteries are a type of rechargeable battery that uses zinc and bromine in the electrolytes to store and release electrical energy. The relatively high energy density and long lifespan make them an ideal choice for grid-scale energy storage applications. Abstract: Zinc-bromine flow batteries (ZBFBs) are promising candidates for the large-scale stationary energy storage …

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Bioinspired gradient scaffolds for osteochondral tissue engineering

Article, Review Article / By

The difficulty in repairing osteochondral injuries is mainly the complex gradient properties of natural osteochondral structures. This review discusses the development of various osteochondral tissue engineering scaffolds with gradient properties, including pore gradients, composition gradients, and inducing factor gradients, discusses the future research focus of gradient scaffolds and the trend of osteochondral tissue engineering, and …

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The pharmacology and therapeutic role of cannabidiol in diabetes

Article, Perspective / By

Schematic illustration of the therapeutic role and drug development of cannabidiol (CBD) for diabetes. This article comprehensively summarizes the pharmacology and therapeutic role of CBD for diabetes and its complications. Furthermore, the strategies for identifying molecular targets of CBD and developing CBD analogues with greater therapeutic potency have been proposed. Abstract: In recent years, cannabidiol …

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Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment

Article, Research Article / By

Overexpression of the EGFR is found in up to 74% of bladder cancer (BCa) tissue. Two natural products that were found, triptolide (TPL) and hesperidin (HSP), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles in a water environment, which not only remarkably improved their bioavailability and therapeutic but …

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