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Harnessing stimuli-responsive biomaterials for advanced biomedical applications

Article, Review Article / By

The application of physical stimulation biomaterials based on ultrasound, light, electricity, and magnetism in the field of biomedicine is summarized, as electrical stimulation of nerve regeneration, electrical stimulation of skin regeneration, electrical stimulation of bone regeneration, photothermal/photodynamic, ultrasound stimulated tissue repair, ultrasonic controlled release, targeting/controlled release, magnetic stimulation tissue repair. Abstract: Cell behavior is intricately …

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Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Article, Review Article / By

Within this review, an in-depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune-mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs. Furthermore, the review delves into the …

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Advancements and challenges in brain cancer therapeutics

Article, Review Article / By

The review summarizes various treatment options for brain tumors, focusing on their mechanisms, potential side effects, and recent developments. It emphasizes the need for personalized, multi-modal treatment approaches in this rapidly evolving field, balancing efficacy and patient safety. The complexity and diversity of brain tumor treatments are highlighted, advocating for ongoing research and technological advancements …

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Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer

Article, Research Article / By

Herein, a photothermal nanoplatform based on ferric ions (Fe3+), naturally-derived polyphenol gallic acid (GA), model antigen ovalbumin (OVA), and l-buthionine sulfoximine (BSO) was constructed, which can supply with GPX4 inhibitors to eliminate colorectal cancer (CRC) by trapping the tumor cells in the ferroptosis and immunotherapy cascade loop. This strategy provides a promising approach to significantly …

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Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches

Article, Research Article / By

The readout circuit based on inkjet-printed deep-subthreshold operated thin film transistors (TFTs) based on amorphous indium-gallium-zinc oxide (a-IGZO) successfully digitalizes analog sensor data and provides easy-to-detect visual identification of the sensor signal at a preset threshold crossover using high-current oxide TFTs. Notably, the complete smart sensor patch is shown to operate at a low voltage …

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High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption

Article, Research Article / By

Matrix-free solid-state RTP with an average lifetime of 0.50 s is realized in the carbon dots (CDs) synthesized by the one-pot hydrothermal process of powder made of feather wastes. The room-temperature phosphorescence lifetime is further prolonged to 1.97 s by employing polyvinyl alcohol (PVA) and phytic acid (PA). Subsequently, a novel CDs/PVA/PA ink is successfully …

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Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing

Article, Research Article / By

An intelligent acid responsive ZIF-8 nanoparticle (CCM + TTD@ZIF-8 NPs) is proposed and is used to promote the healing of burns and infected wounds. It can effectively target bacteria and achieve bacterial imaging under blue light irradiation, effectively releasing CCM and TTD in acidic environments, thereby inhibiting the inflammatory microenvironment and promoting wound healing. Abstract: …

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Article, Research Article / By

Trilayer scaffolds were fabricated for biomimicking the anatomical structure of the uterine tissue. They could sustainably release estradiol and were able to transform into curved structures to meet the curvature of uterine tissue. They therefore have a high potential for uterine regeneration. Abstract: Scaffold-based tissue engineering provides an efficient approach for repairing uterine tissue defects …

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A perspective of lipid nanoparticles for RNA delivery

Article, Perspective / By

This perspective summarizes the approaches for the preparation of lipid nanoparticles (LNPs), the key characterization parameters, in vitro cell experiments, and in vivo animal experiments. The authors hope this perspective can offer valuable guidance to researchers who enter the field of RNA-based LNPs and help them understand the crucial parameters that RNA-based LNPs demand. Abstract: …

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Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations

Article, Review Article / By

We conducted a critical evaluation of decellularization techniques, quality control, cross-linking, and modification methods for dECM scaffolds derived from different sources. The functional properties of dECM components as well as their recent applications in multi-organ tissue engineering and biomedicine were thoroughly reviewed. This work aims to discuss and summarize the current challenges and limitations of …

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