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Rethinking the pathway to sustainable fire retardants

Rethinking the pathways to sustainable fire retardants, from the perspective of sustainability, costs, and efficiency. Abstract: Flame retardants are currently used in a wide range of industry sectors for saving lives and property by mitigating fire hazards. The growing fire safety requirements for materials boost an escalating demand for consumption of fire retardants. This has …

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Dynamic regulation of drug biodistribution by turning tumors into decoys for biomimetic nanoplatform to enhance the chemotherapeutic efficacy of breast cancer with bone metastasis

The schematic diagram of EMM@DJHAD NPs destroys tumor cells via the synergism of DAC and JTC. The former enriches the level of gasdermin E in tumor by demethylation of the DFNA5 gene and the latter activates the caspase-3 pathway, triggering pyroptosis of tumor cells. Importantly, JTC-mediated µ-opioid receptor (MOR) inhibition is responsible for both tumor suppression and …

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Adoptive cell therapy for cancer treatment

This perspective describes multiple types of commonly used adoptive cell therapy with an emphasis on their clinical progress. In addition, the challenges and opportunities of adoptive cell therapy for future clinical translation are described from the authors’ point of view. Abstract: Adoptive cell therapy (ACT) is a rapidly growing anti-cancer strategy that has shown promise …

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Recent progress of metal-based nanomaterials with anti-tumor biological effects for enhanced cancer therapy

Metal-based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely biological effects. Due to the superior advantages of metal-based nanomaterials and the characteristics of the tumor microenvironment, we will summarize the recent progress of the anti-tumor biological effects of metal-based nanomaterials. Based on the …

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In vivo synergistic tumor therapies based on copper sulfide photothermal therapeutic nanoplatforms

The synergism between tumor photothermal therapy (PTT) with copper sulfide nanoparticles and other therapies is discussed such as chemotherapy, radiotherapy, dynamic therapies (photodynamic, chemodynamic, and sonodynamic therapy), immunotherapy, gene therapy, gas therapy, and magnetic hyperthermia. Further, a combination of two treatments and at least two therapies with PTT is summarized. Abstract: Tumor cells may be …

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Recent advances in enzymatic biofuel cells enabled by innovative materials and techniques

Enzymatic biofuel cells (EBFCs) have garnered significant research interest due to their capacity to power implantable bioelectronics, portable devices, and biosensors by utilizing biomass as fuel. To depict the current progress of EBFC and address the challenges it faces, this review traces back the evolution of EBFC and focuses on contemporary advances. Abstract: The past …

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Gel/hydrogel-based in situ biomaterial platforms for cancer postoperative treatment and recovery

Gel/Hydrogel-based in situ biomaterial platforms are promising candidates for cancer postoperative treatment and recovery, which decrease the risk of poor prognosis caused by postoperative complications. This review summarized the properties and synthesis procedures of gel/hydrogel-based biomaterials and highlighted their advantages in postoperative tumor recurrence and metastasis inhibition by various drug loading and enhanced local delivery. …

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Alteration of chromatin high-order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells

Our research reveals the spatial chromatin structural difference between colorectal cancer (CRC) cells and oxaliplatin resistant cells based on the DLO Hi-C and other epigenetic omics experiments. More importantly, we provide a series of A/B compartment switching genes as potential targets for oxaliplatin-resistant cancer treatment and find a new way to investigate drug resistance behavior …

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Hydrogenated silicene nanosheet functionalized scaffold enables immuno-bone remodeling

A novel 2D hydrogenated-silicon nanosheet (H-Si NSs) is integrated and functionalized into a β-tricalcium phosphate scaffold (H-Si TCP) for immuno-bone remodeling in our study. H-Si NSs has great ROS-responsive, immunoregulatory, and osteo-promotive property and H-Si TCP can provide sufficient ingredients and greatly improve bone regeneration step by step through osteoimmunomodulation-guided biodegradation in vivo. Abstract: An …

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Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

In this review, we generalized the unique properties of CDs, CD-related supramolecular nanocarriers, supramolecular controlled release systems, and targeting systems based on CDs, and introduced the paradigms of these nanomedicines. In addition, we also discussed the prospects and challenges of CD-based supramolecular nanomedicines to facilitate the development and clinical translation of these nanomedicines. Abstract: In …

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