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Scientific issues of zinc-bromine flow batteries and mitigation strategies

Zinc-bromine flow batteries are a type of rechargeable battery that uses zinc and bromine in the electrolytes to store and release electrical energy. The relatively high energy density and long lifespan make them an ideal choice for grid-scale energy storage applications. Abstract: Zinc-bromine flow batteries (ZBFBs) are promising candidates for the large-scale stationary energy storage …

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Bioinspired gradient scaffolds for osteochondral tissue engineering

The difficulty in repairing osteochondral injuries is mainly the complex gradient properties of natural osteochondral structures. This review discusses the development of various osteochondral tissue engineering scaffolds with gradient properties, including pore gradients, composition gradients, and inducing factor gradients, discusses the future research focus of gradient scaffolds and the trend of osteochondral tissue engineering, and …

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The pharmacology and therapeutic role of cannabidiol in diabetes

Schematic illustration of the therapeutic role and drug development of cannabidiol (CBD) for diabetes. This article comprehensively summarizes the pharmacology and therapeutic role of CBD for diabetes and its complications. Furthermore, the strategies for identifying molecular targets of CBD and developing CBD analogues with greater therapeutic potency have been proposed. Abstract: In recent years, cannabidiol …

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Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment

Overexpression of the EGFR is found in up to 74% of bladder cancer (BCa) tissue. Two natural products that were found, triptolide (TPL) and hesperidin (HSP), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles in a water environment, which not only remarkably improved their bioavailability and therapeutic but …

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Biomembrane force probe (BFP): Design, advancements, and recent applications to live-cell mechanobiology

This review provides a thorough examination of the traditional BFP-DFS configurations, highlighting notable progressions such as the introduction of the dual biomembrane force probe (dBFP) and the fluorescence biomembrane force probe (fBFP). The significant contributions of the BFP-DFS to cancer biology, thrombosis, and inflammation are explored, underscoring its potential for unveiling therapeutic insights. Additionally, forthcoming …

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Glucose oxidase-instructed biomineralization of calcium-based biomaterials for biomedical applications

In this review, the state-of-the-art studies on glucose oxidase (GOx)-mineralized calcium-based biomaterials (CaXs) are introduced with an emphasis on their application in various biomedical fields including disease diagnosis, cancer treatment, and diabetes management. The current challenges and future perspectives of GOx-mineralized CaXs are discussed, which is expected to promote further studies on these smart GOx-mineralized …

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The potential role of synovial cells in the progression and treatment of osteoarthritis

Synovial cells play an important role in the progression of osteoarthritis (OA). This article summarizes the biological functions of the synovium, synovial cells, and synovial fluid, discussing their potential roles in OA. Preclinical and clinical studies related to targeting synovial cells and synovial mesenchymal stem cell (SMSC)-based treatments are also included. This paper will be …

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Toward high-efficiency photovoltaics-assisted electrochemical and photoelectrochemical CO2 reduction: Strategy and challenge

This study explores methodologies for establishing a low–carbon economy by reducing atmospheric CO2 through sustainable electrochemical and photoelectrochemical CO2 reduction reactions. It presents diverse fabrication approaches for efficient catalysts.To surmount the limitations of these systems, photovoltaic systems are introduced, and the study highlights contemporary impediments and potential remedies, encompassing inadequate energy conversion rates, exorbitant expenses, and industrial …

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Atomically Fe-anchored MOF-on-MOF nanozyme with differential signal amplification for ultrasensitive cathodic electrochemiluminescence immunoassay

An ultrasensitive cathodic electrochemiluminescence immunoassay was developed by designing atomically Fe-anchored MOF-on-MOF nanozymes (CoNi-MOF@PCN-224/Fe) as ECL electrode materials and plasmonic Ag/AuNCs as high-efficient co-reactant quenchers. The proposed differential signal amplification strategy endowed the immunoassay with superior detection ability, which provide more possibilities for the ultrasensitive detection of disease markers in clinical diagnosis. Abstract: The successful …

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Visual genetic typing of glioma using proximity-anchored in situ spectral coding amplification

This research developed a novel multiplexed imaging method of RNA mutations, named proximity-anchored in situ spectral coding amplification (ProxISCA), enabling visual typing of brain gliomas with different pathological grades at the single-cell and tissue levels. ProxISCA provides a tool for glioma research and precise diagnosis, which can reveal the relationship between cellular heterogeneity and glioma …

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