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Nanomaterials-assisted metabolic analysis toward in vitro diagnostics

Article, Review Article / By

Nanomaterials have found extensive applications in the metabolic analysis of diverse bio-specimens, with efficient selectivity and sensitivity. The nanomaterial-based metabolic analysis is always accompanied by accurate quantitation of targeted metabolite biomarkers and high-throughput profiling of untargeted metabolic fingerprints, adding practical value to in vitro diagnostics. Its further developments will have far-reaching implications for the research …

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Electrodeposition: An efficient method to fabricate self-supported electrodes for electrochemical energy conversion systems

Article, Review Article / By

The high-performance electrocatalysts have attracted significant attention to develop efficient energy conversion systems for clean production of hydrogen, hydrocarbon compounds, and ammonia. Electrodeposition is a simple method for fabricating the electrocatalysts with facile control of compositional and morphological properties in aqueous solutions under mild conditions. In this review, recent progress in electrodeposited electrocatalysts is summarized. …

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Light responsive nucleic acid for biomedical application

Article, Review Article / By

Light-responsive nucleic acids have attracted much attention in the biomedical field due to their properties of remote control and high spatiotemporal resolution. This review summarizes recent research progress in light-responsive nucleic acid systems. The challenges in this field are discussed and future prospects are prospected. This review will provide inspiration for the rational design of …

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Exceptional point protected robust on-chip optical logic gates

Article, Research Article / By

Non-Hermitian physical principles are introduced into the design of on-chip photonic devices toward high robustness. As a proof-of-concept, an exclusive-or gate on silicon-on-insulator platform is designed by employing the exceptional point encirclement physics. The device performance is extremely robust to structural parameter disturbances, owing to the protection of the photon phase by the topological structure around …

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Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

Article, Short Communication / By

We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial organization of lysosomes against mitochondria during mitophagy by using super resolution microscopy. Abstract: Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome …

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Drug-grafted DNA as a novel chemogene for targeted combinatorial cancer therapy

Article, Research Article / By

A new type of targeted chemogene is constructed through site-specific grafting camptothecins onto a phosphor othioate DNA containing antisense and aptamer segments. With simple and precise structure, the targeted chemogene shows hallmark properties in both in vitro and in vivo evaluations, including active targeting capability, vigorous gene regulation pitency, and prominent antiumor effect, providing new …

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Aggregation-induced emission luminogens for augmented photosynthesis

Article, Perspective / By

Augmented photosynthesis will increase the amount of CO2 sequestration and provide sustainable food and biofuel. Luminescent materials that shift the wavelength to a more usable range could augment photosynthesis. Recent findings of augmented photosynthesis by luminescent materials especially aggregation-induced emission luminogens were summarized and a bright prospect has been speculated to inspire more research efforts. Abstract: …

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Organic radical materials in biomedical applications: State of the art and perspectives

Article, Perspective / By

Organic radicals usually show unique chemical reactivities and paramagnetism, which have aroused wide concern in physical, chemical, and biological fields for many years. Here we summarized the biomedical applications of radical-containing materials in imaging/sensing (e.g., EPR imaging, spin labeling, magnetic resonance imaging, and fluorescence imaging ) and photo-triggered therapies (photodynamic therapy and photothermal therapy). We …

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Bioactive inorganic particles-based biomaterials for skin tissue engineering

Article, Review Article / By

The inorganic biomaterials for wound healing have aroused widespread concern in the field of tissue engineering. The three main forms of application of inorganic particles for skin repair are summarized based on the complexity of material system. The representative types of inorganic biomaterials and fabrication technology of wound dressings are presented. Abstract: The challenge for …

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Advances in metal graphitic nanocapsules for biomedicine

Article, Review Article / By

In this review, we summary the preparation, classification, and properties of versatile metal graphitic nanocapsules, and then introduce the recent progress of their applications in biodetection, bioimaging, and therapy in detail. In addition, challenges and their development prospects in biomedicine are also discussed. We expect the metal graphitic nanocapsules will advance the development of future …

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