The coexistence of diabetes mellitus (DM) and tuberculosis (TB) presents a significant global burden, with DM being recognized as a major risk factor for TB. This review comprehensively analyzes the immunological aspects of DM-TB comorbidity, shedding light on the impact of DM on TB pathogenesis and immune responses. Moreover, the review explores the effects of …
This summary diagram comprehensively and reasonably reviews the evolution of BDT-based donor materials over the last 20 years by subdividing the molecular design strategies of main-chain engineering, side-chain engineering as well as other engineering based on the detailed molecular structure of BDT-based polymer donors and small molecule donors. Abstract: In recent decades, the demand for …
The review provides a comprehensive overview of the development and application of tumor cell membrane (TCM)-based vaccines for cancer protection and therapy. A detailed description of structure of the TCM-wrapped particles (TCMPs), modification of TCMPs, membrane hybridization, and related adjuvants is given. As a derivative of TCM, the vaccines for tumor-derived-extracellular vesicles (TEVs) are also …
Tumor cell membrane-based vaccines: A potential boost for cancer immunotherapy Read More »
There is an increasing body of evidence suggesting the involvement of long non-coding RNAs (lncRNAs) in neural development and function. Nevertheless, the relationship between lncRNAs and Alzheimer’s disease (AD) remains uncertain. Previous genome-wide association studies (GWAS) have linked cancer susceptibility candidate 15 (CASC15) with AD. This study aims to comprehensively investigate the characteristics and mechanisms …
A comprehensive review summarizes recent advancements in nitric oxide (NO) gas-assisted cancer photothermal treatment. It commences by providing various types of NO donors/precursors for dual-modal therapy. Subsequently, chemotherapy, photodynamic therapy, alkyl radical therapy, radiation therapy, immunotherapy, chemodynamic therapy, starvation therapy, Ca2+ overload, and ferroptosis are incorporated for triple- and tetra-modal treatment. Abstract: Photothermal therapy (PTT) …
Emerging nitric oxide gas-assisted cancer photothermal treatment Read More »
Metal-based smart nanosystems show great potential in modulating each phase of the cancer immunity cycle to boost anticancer immune responses against tumor growth, recurrence, and metastasis mainly by inducing immunogenic cell death, repolarizing protumoral M2 tumor associated macrophages(TAMs) into antitumoral M1 phenotype, and activating the cGAS-STING signaling pathway. Abstract: Metals are an emerging topic in …
Metal-based smart nanosystems in cancer immunotherapy Read More »
Cell membrane-coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. This review provides a comprehensive overview of the recent advancements in utilizing CMNPs as effective drug delivery vehicles for cancer therapy, including synthesis methods, functionalization strategies, preclinical studies utilizing CMNPs for cancer therapy, and future directions and challenges of clinical potential …
Innovative utilization of cell membrane-coated nanoparticles in precision cancer therapy Read More »
This study aims to understand ATP synthase inhibitory factor 1’s (ATPIF1’s) role in peripheral nerve regeneration (PNR) using a murine model of sciatic nerve crush injury. Histological exams and behavior assessments revealed ATPIF1 absence hindered nerve tissue reconstruction, delaying sensory and functional recovery. RNA-sequencing showed reduced immune responses in ATPIF1 knockout mice, particularly CCR2/CCL2 signaling-mediated …
Deformable nanocarriers with various morphological transformations for diferent potential applications. Abstract: Recently, the field of nanomedicine has witnessed substantial advancements in the development of nanocarriers for targeted drug delivery, emerges as promising platforms to enhance therapeutic efficacy and minimize adverse effects associated with conventional chemotherapy. Notably, deformable nanocarriers have garnered considerable attention due to their …
Deformable nanocarriers for enhanced drug delivery and cancer therapy Read More »
The current monitoring technologies for biological loads in sewage exhibit drawbacks, including low detection efficiency and insufficient accuracy. The authors’ research team has developed an innovative approach that harnesses the power of the CRISPR/Cas12a system within an automated robot-driven photoelectrochemical biosensing platform. This platform allows early detection and tracking of infectious disease outbreaks, providing timely …
