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Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials

Functional subcellular organelle mitochondria are emerging as a crucial player and driver of cancer. Precision medicine targeting mitochondria can change nutrient availability and redox homeostasis in cancer cells. This review highlights how the modification capable of manipulating nanomaterials for reactive oxygen species (ROS) generation strategies can influence the rate of mitochondrial ROS production and their …

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Nanodrugs with intrinsic radioprotective exertion: Turning the double-edged sword into a single-edged knife

The realization of ideal radioprotectors has long been the hotspot in radiation medicine. Recently, nano-technology is equipping the traditional radioprotectors with better bioavailability, less toxicity, etc. This review summarized the development, design innovations, applications, challenges, and prospects of the intrinsic antiradiation nanomedicines, and presented a comprehensive overview, in-depth analysis, and an updated understanding of the …

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Mobile mechanical signal generator for macrophage polarization

Great progress has been made in ingenious bone tissue engineering for osteonecrosis of the femoral head (ONFH) treatment in the last decades. In this review, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. We also propose insights on the current challenges of these advances in the clinic and the …

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Composite materials based on covalent organic frameworks for multiple advanced applications

In this review, we have summarized the development of different types of COFs-based composites reported so far, with particular focus on the representative applications of COFs-based composites, and the in-depth insight into their current challenges and future development prospects. We anticipate that this review may provide some inspiration and insights for the further development of …

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Ultralow-power in-memory computing based on ferroelectric memcapacitor network

We demonstrate a robust memcapacitor by stacking ferroelectric capacitor on the metal-insulator-semiconductor structure. It possesses a long retention time of more than 104 s and well endurance of 109 cycles. Ultralow-power in-memory computing based on ferroelectric memcapacitor array intrinsically consumes zero energy in memcapacitors themselves. It sheds light on an ultralow-power neural hardware based on ferroelectric memcapacitors. …

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Aptamer-functionalized field-effect transistor biosensors for disease diagnosis and environmental monitoring

Aptamer-functionalized field-effect transistor (FET) biosensors with merits of fast response speed, ease of miniaturization, and integration offer an attractive solution to disease diagnosis and environmental monitoring. This review is focusing on the development of aptamer-functionalized FET biosensors from sensing mechanism to functionalization strategy to biological application level, combined with the latest research and in-depth outlook, …

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One-dimensional carbon based nanoreactor fabrication by electrospinning for sustainable catalysis

Owing to the synergy between highly dispersed active sites and particular substrates with the one-dimensional nanostructure, fibrous carbon-based nanoreactors have exhibited fascinating electrocatalytic performance in electrochemical reactions. Therefore, one-dimensional fibrous carbon-based nanoreactors from the electrospun fabrication process have been used in catalyzing oxygen reduction reaction, oxygen evolution reaction, and hydrogen evolution reaction electrochemical reactions. Abstract: …

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Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency

Hippocampal Cntnap4 deficiency was associated with cognitive impairment via inducing pro-inflammatory response in females. A biomimetic microglial nanoparticle system (MNPs@PLX) was established for precise microglial delivery of FDA-approved PLX3397 to attenuate cognitive decline, dysfunctional synaptic plasticity, and pro-inflammatory response in female heterozygous Cntnap4 knockout mice. This study indicates that microglial supplementation of PLX3397 may serve as an intervention for …

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Mesoporous silica/organosilica nanoparticles for cancer immunotherapy

Silica based nanoparticles have been extensively applied in nanomedicine including cancer immunotherapy. In this review, the applications of mesoporous silica nanoparticles (MSN), mesoporous organosilica nanoparticles (MON), and metal-doped MSN/MON in the field of cancer immunotherapy and tumor microenvironment regulation are comprehensively summarized by highlighting the structural and compositional attributes of the silica-based nanoplatforms. Abstract: Cancer …

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Biomimetic and bioinspired nano-platforms for cancer vaccine development

Harnessing the immune system to attack the tumor with cancer vaccines is being intensively studied. Nowadays, biomimetic and bioinspired nanotechnology provides new impetus for the designing concepts of cancer vaccines. The specific behaviors and endogenous molecules of each type of living entity (eukaryotic cell or microorganism) offer unique features to address specific needs for cancer …

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