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Conducting polymer hydrogels based on supramolecular strategies for wearable sensors

Article, Review Article / By

This review summarizes typical supramolecular strategies for developing high-performance conducting polymer hydrogels (CPHs) and elucidates their properties relevant to wearable sensors. Additionally, it discusses the fabrication methods and classification of supramolecular CPH sensors and their latest applications in wearable devices. Finally, the review addresses these sensors’ challenges and provides suggestions for future developments. Abstract: Conductive …

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Motorizing the buckled blister for rotary actuation

Article, Research Article / By

We explore the rotation of a buckled blister constrained inside an outer ring. The rotation of buckled blister iss actuated via a localized change of curvature, and lower energy-supply is required to initiate the snap-through of buckling compared to conventional bistable mechanism. We experimentally demonstrate the controllability in rotational speed and output torque for a bimetallic …

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Neural interfaces: Bridging the brain to the world beyond healthcare

Article, Perspective / By

This perspective explores diverse neural interfaces in the brain, offering transformative possibilities for engaging with our environment and enhancing communication. Emphasis is placed on the role of both non-invasive and invasive neural interfaces in transforming practical applications beyond the realm of healthcare, emphasizing the promising implications for remote control, mind connectivity, and integrated urban design. …

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Calcium-dependent antimicrobials: Nature-inspired materials and designs

Article, Review Article / By

The paper summarizes calcium’s merits in coordination, hydration, ionization, and stereochemistry for acting as a structural former or trigger in biological systems, illuminates its natural roles in pathogens and the immune systems, and discusses its applications in infection medications. It shows that calcium is at the nexus of antimicrobial defense but is overlooked to some …

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Unveiling the promise: Exosomes as game-changers in anti-infective therapy

Article, Review Article / By

A comprehensive review to reveal new insights into exosomes’ distinctiveness, the growing availability of new analytical tools that drive the development of next-generation synthetic systems were presented. Herein, light is shed on exosomes as drug delivery vehicles in anti-infective therapy. Additionally, the benefits and limitations of employing exosomes as vehicles for therapeutic drug delivery are …

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Facile construction of dual-response super-resolution probes for tracking organelles dynamics

Article, Research Article / By

CPC probe with dual response to LDs polarity and mitochondrial ONOO− developed using a toolkit, which indicates an increase in homogeneity of lipid droplets and fibrous-like mitochondria during ferroptosis that inhibits LDs–mitochondrial interactions. Abstract: Super-resolution imaging techniques, such as structured illumination microscopy (SIM), have enabled researchers to obtain nanoscale organelle-level outputs in living systems, but …

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A self-assembled, genetically engineered, irradiated tumor cell debris vaccine

Article, Research Article / By

Sun et al. report on a personized cancer vaccine generated by irradiating GM-CSF overexpressed tumor cells (providing antigens and stimulation signal for APCs), covalent conjugation with hyaluronic acid (improving the persistence of antigen stimulation). The engineered vaccine activated antitumor immunity responses and prevented tumor growth in mice with a single immunization. Abstract: Vaccine-based therapeutics for …

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Recent advances in bacteria-based platforms for inflammatory bowel diseases treatment

Article, Review Article / By

Recent studies on bacteria-based platforms for the treatment of inflammatory bowel disease (IBD) through immunomodulation, antioxidative stress, barrier restoration, and microbial regulation are comprehensively reviewed. Current dilemmas and future development prospects of integrated IBD-targeting bacterial platforms were also discussed. Abstract: Inflammatory bowel disease (IBD) is a recurring chronic inflammatory disease. Current treatment strategies are aimed …

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Recent advances in mitochondria-targeting theranostic agents

Article, Review Article / By

Possessing diagnostic imaging and therapeutic functions, mitochondria-targeted theranostic agents can significantly optimize the treatment process and promote precision medicine. This review summarizes the research progress on these agents and the commonly used diagnostic modalities and therapeutic strategies. It also discusses various therapeutic agent categories and their disease applications, addressing unresolved issues and envisioning future directions …

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Recent progress in quantitative analysis of self-assembled peptides

Article, Review Article / By

Self-assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. This review summarizes the techniques for quantitative analysis, including imaging-based quantitative techniques, chromatographic technique, and computational approach. These techniques can facilitate the investigation of the structure, properties, biomedical applications, and even supramolecular assembly processes of self-assembled peptides. The perspective …

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