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Alteration of chromatin high-order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells

Article, Research Article / By

Our research reveals the spatial chromatin structural difference between colorectal cancer (CRC) cells and oxaliplatin resistant cells based on the DLO Hi-C and other epigenetic omics experiments. More importantly, we provide a series of A/B compartment switching genes as potential targets for oxaliplatin-resistant cancer treatment and find a new way to investigate drug resistance behavior …

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Hydrogenated silicene nanosheet functionalized scaffold enables immuno-bone remodeling

Article, Research Article / By

A novel 2D hydrogenated-silicon nanosheet (H-Si NSs) is integrated and functionalized into a β-tricalcium phosphate scaffold (H-Si TCP) for immuno-bone remodeling in our study. H-Si NSs has great ROS-responsive, immunoregulatory, and osteo-promotive property and H-Si TCP can provide sufficient ingredients and greatly improve bone regeneration step by step through osteoimmunomodulation-guided biodegradation in vivo. Abstract: An …

Hydrogenated silicene nanosheet functionalized scaffold enables immuno-bone remodeling Read More »

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins

Article, Review Article / By

In this review, we generalized the unique properties of CDs, CD-related supramolecular nanocarriers, supramolecular controlled release systems, and targeting systems based on CDs, and introduced the paradigms of these nanomedicines. In addition, we also discussed the prospects and challenges of CD-based supramolecular nanomedicines to facilitate the development and clinical translation of these nanomedicines. Abstract: In …

Supramolecular nanomedicines based on host–guest interactions of cyclodextrins Read More »

Recent advances of cellular stimulation with triboelectric nanogenerators

Article, Review Article / By

Triboelectric nanogenerators (TENGs) are portable and wearable energy collection devices. TENGs have five working modes, whose principle can be summarized as the conversion of mechanical energy to electrical energy by triboelectrification and electrostatic induction between the two materials. According to this, TENGs can be used on cell stimulation, which plays a variety of biological effects …

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Characterization of various tandem solar cells: Protocols, issues, and precautions

Article, Perspective / By

Various structures are adopted in tandem solar cells (TSCs) to overcome the efficiency limit of the single junction solar cell. Fair and accurate evaluation of the various TSCs requires understanding the effectiveness and limitations of their characterization methods. Various types of TSCs are summarized. And characterization methods of TSCs are discussed. Abstract: In the search …

Characterization of various tandem solar cells: Protocols, issues, and precautions Read More »

Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials

Article, Review Article / By

Functional subcellular organelle mitochondria are emerging as a crucial player and driver of cancer. Precision medicine targeting mitochondria can change nutrient availability and redox homeostasis in cancer cells. This review highlights how the modification capable of manipulating nanomaterials for reactive oxygen species (ROS) generation strategies can influence the rate of mitochondrial ROS production and their …

Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials Read More »

Nanodrugs with intrinsic radioprotective exertion: Turning the double-edged sword into a single-edged knife

Article, Review Article / By

The realization of ideal radioprotectors has long been the hotspot in radiation medicine. Recently, nano-technology is equipping the traditional radioprotectors with better bioavailability, less toxicity, etc. This review summarized the development, design innovations, applications, challenges, and prospects of the intrinsic antiradiation nanomedicines, and presented a comprehensive overview, in-depth analysis, and an updated understanding of the …

Nanodrugs with intrinsic radioprotective exertion: Turning the double-edged sword into a single-edged knife Read More »

Mobile mechanical signal generator for macrophage polarization

Article, Research Article / By

Great progress has been made in ingenious bone tissue engineering for osteonecrosis of the femoral head (ONFH) treatment in the last decades. In this review, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. We also propose insights on the current challenges of these advances in the clinic and the …

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Composite materials based on covalent organic frameworks for multiple advanced applications

Article, Review Article / By

In this review, we have summarized the development of different types of COFs-based composites reported so far, with particular focus on the representative applications of COFs-based composites, and the in-depth insight into their current challenges and future development prospects. We anticipate that this review may provide some inspiration and insights for the further development of …

Composite materials based on covalent organic frameworks for multiple advanced applications Read More »

Ultralow-power in-memory computing based on ferroelectric memcapacitor network

Article, Research Article / By

We demonstrate a robust memcapacitor by stacking ferroelectric capacitor on the metal-insulator-semiconductor structure. It possesses a long retention time of more than 104 s and well endurance of 109 cycles. Ultralow-power in-memory computing based on ferroelectric memcapacitor array intrinsically consumes zero energy in memcapacitors themselves. It sheds light on an ultralow-power neural hardware based on ferroelectric memcapacitors. …

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