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Biomembrane force probe (BFP): Design, advancements, and recent applications to live-cell mechanobiology

Article, Review Article / By

This review provides a thorough examination of the traditional BFP-DFS configurations, highlighting notable progressions such as the introduction of the dual biomembrane force probe (dBFP) and the fluorescence biomembrane force probe (fBFP). The significant contributions of the BFP-DFS to cancer biology, thrombosis, and inflammation are explored, underscoring its potential for unveiling therapeutic insights. Additionally, forthcoming …

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Glucose oxidase-instructed biomineralization of calcium-based biomaterials for biomedical applications

Article, Review Article / By

In this review, the state-of-the-art studies on glucose oxidase (GOx)-mineralized calcium-based biomaterials (CaXs) are introduced with an emphasis on their application in various biomedical fields including disease diagnosis, cancer treatment, and diabetes management. The current challenges and future perspectives of GOx-mineralized CaXs are discussed, which is expected to promote further studies on these smart GOx-mineralized …

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The potential role of synovial cells in the progression and treatment of osteoarthritis

Article, Review Article / By

Synovial cells play an important role in the progression of osteoarthritis (OA). This article summarizes the biological functions of the synovium, synovial cells, and synovial fluid, discussing their potential roles in OA. Preclinical and clinical studies related to targeting synovial cells and synovial mesenchymal stem cell (SMSC)-based treatments are also included. This paper will be …

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Toward high-efficiency photovoltaics-assisted electrochemical and photoelectrochemical CO2 reduction: Strategy and challenge

Article, Review Article / By

This study explores methodologies for establishing a low–carbon economy by reducing atmospheric CO2 through sustainable electrochemical and photoelectrochemical CO2 reduction reactions. It presents diverse fabrication approaches for efficient catalysts.To surmount the limitations of these systems, photovoltaic systems are introduced, and the study highlights contemporary impediments and potential remedies, encompassing inadequate energy conversion rates, exorbitant expenses, and industrial …

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Atomically Fe-anchored MOF-on-MOF nanozyme with differential signal amplification for ultrasensitive cathodic electrochemiluminescence immunoassay

Article, Research Article / By

An ultrasensitive cathodic electrochemiluminescence immunoassay was developed by designing atomically Fe-anchored MOF-on-MOF nanozymes (CoNi-MOF@PCN-224/Fe) as ECL electrode materials and plasmonic Ag/AuNCs as high-efficient co-reactant quenchers. The proposed differential signal amplification strategy endowed the immunoassay with superior detection ability, which provide more possibilities for the ultrasensitive detection of disease markers in clinical diagnosis. Abstract: The successful …

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Visual genetic typing of glioma using proximity-anchored in situ spectral coding amplification

Article, Research Article / By

This research developed a novel multiplexed imaging method of RNA mutations, named proximity-anchored in situ spectral coding amplification (ProxISCA), enabling visual typing of brain gliomas with different pathological grades at the single-cell and tissue levels. ProxISCA provides a tool for glioma research and precise diagnosis, which can reveal the relationship between cellular heterogeneity and glioma …

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Rethinking the pathway to sustainable fire retardants

Article, Perspective / By

Rethinking the pathways to sustainable fire retardants, from the perspective of sustainability, costs, and efficiency. Abstract: Flame retardants are currently used in a wide range of industry sectors for saving lives and property by mitigating fire hazards. The growing fire safety requirements for materials boost an escalating demand for consumption of fire retardants. This has …

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Dynamic regulation of drug biodistribution by turning tumors into decoys for biomimetic nanoplatform to enhance the chemotherapeutic efficacy of breast cancer with bone metastasis

Article, Research Article / By

The schematic diagram of EMM@DJHAD NPs destroys tumor cells via the synergism of DAC and JTC. The former enriches the level of gasdermin E in tumor by demethylation of the DFNA5 gene and the latter activates the caspase-3 pathway, triggering pyroptosis of tumor cells. Importantly, JTC-mediated µ-opioid receptor (MOR) inhibition is responsible for both tumor suppression and …

Dynamic regulation of drug biodistribution by turning tumors into decoys for biomimetic nanoplatform to enhance the chemotherapeutic efficacy of breast cancer with bone metastasis Read More »

Adoptive cell therapy for cancer treatment

Article, Perspective / By

This perspective describes multiple types of commonly used adoptive cell therapy with an emphasis on their clinical progress. In addition, the challenges and opportunities of adoptive cell therapy for future clinical translation are described from the authors’ point of view. Abstract: Adoptive cell therapy (ACT) is a rapidly growing anti-cancer strategy that has shown promise …

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Recent progress of metal-based nanomaterials with anti-tumor biological effects for enhanced cancer therapy

Article, Review Article / By

Metal-based nanomaterials have attracted broad attention recently due to their unique biological physical and chemical properties after entering tumor cells, namely biological effects. Due to the superior advantages of metal-based nanomaterials and the characteristics of the tumor microenvironment, we will summarize the recent progress of the anti-tumor biological effects of metal-based nanomaterials. Based on the …

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