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Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial organization of lysosomes against mitochondria during mitophagy by using super resolution microscopy. Abstract: Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome …

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Drug-grafted DNA as a novel chemogene for targeted combinatorial cancer therapy

A new type of targeted chemogene is constructed through site-specific grafting camptothecins onto a phosphor othioate DNA containing antisense and aptamer segments. With simple and precise structure, the targeted chemogene shows hallmark properties in both in vitro and in vivo evaluations, including active targeting capability, vigorous gene regulation pitency, and prominent antiumor effect, providing new …

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Aggregation-induced emission luminogens for augmented photosynthesis

Augmented photosynthesis will increase the amount of CO2 sequestration and provide sustainable food and biofuel. Luminescent materials that shift the wavelength to a more usable range could augment photosynthesis. Recent findings of augmented photosynthesis by luminescent materials especially aggregation-induced emission luminogens were summarized and a bright prospect has been speculated to inspire more research efforts. Abstract: …

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Organic radical materials in biomedical applications: State of the art and perspectives

Organic radicals usually show unique chemical reactivities and paramagnetism, which have aroused wide concern in physical, chemical, and biological fields for many years. Here we summarized the biomedical applications of radical-containing materials in imaging/sensing (e.g., EPR imaging, spin labeling, magnetic resonance imaging, and fluorescence imaging ) and photo-triggered therapies (photodynamic therapy and photothermal therapy). We …

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Bioactive inorganic particles-based biomaterials for skin tissue engineering

The inorganic biomaterials for wound healing have aroused widespread concern in the field of tissue engineering. The three main forms of application of inorganic particles for skin repair are summarized based on the complexity of material system. The representative types of inorganic biomaterials and fabrication technology of wound dressings are presented. Abstract: The challenge for …

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Advances in metal graphitic nanocapsules for biomedicine

In this review, we summary the preparation, classification, and properties of versatile metal graphitic nanocapsules, and then introduce the recent progress of their applications in biodetection, bioimaging, and therapy in detail. In addition, challenges and their development prospects in biomedicine are also discussed. We expect the metal graphitic nanocapsules will advance the development of future …

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Recent advances in overcoming barriers to cell-based delivery systems for cancer immunotherapy

This review covers the design of cell-based delivery systems for cancer immunotherapy, as well as the significant challenges limiting the efficacy of cell-based immunotherapy and summarizes recent advances in overcoming those barriers to improve cancer treatment outcomes. Abstract: Immunotherapy strategies that use cell-based delivery systems have sparked much interest in the treatment of malignancies, owing …

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Carrier strategies boost the application of CRISPR/Cas system in gene therapy

This review mainly focuses on the state-of-the-art CRISPR delivery systems and their applications, categorized by three types of cargo formats, that is, Cas: single-guide RNA ribonucleoprotein, Cas mRNA and single-guide RNA, and Cas plasmid expressing CRISPR/Cas systems. Abstract: Emerging clustered regularly interspaced short palindromic repeat/associated protein (CRISPR/Cas) genome editing technology shows great potential in gene …

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Strategies for enhancing cancer chemodynamic therapy performance

Chemodynamic therapy (CDT) utilizes endogenous H2O2 in tumor microenvironment to produce cytotoxic hydroxyl radicals through Fenton or Fenton-like reactions. This review outlines the fundamental understanding of Fenton and Fenton-like reactions and their relationship with CDT and highlights recent research advancements in the design of nanosystems to augment Fenton or Fenton-like reactions for enhanced CDT. Perspectives toward …

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Interplaying coordination and ligand effects to break or make adsorption-energy scaling relations

Currently, it is widely accepted that adsorption-energy scaling relations exist or not depending on the similarity of the adsorbates. Here, we show that CO and OH scale linearly or not on Pt alloys depending on the coordination of the adsorption sites. Hence, ligand and geometric effects can be used to modulate scaling relations, thereby opening …

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