the Author

Tau-targeting nanoparticles for treatment of Alzheimer’s disease

Through review of comprehensive literature and research studies, it is found that tau-targeting nanoparticles may posit beneficial applications to AD therapy. By targeting a key molecular mechanism known to propagate AD pathogenesis, tau-targeting nanoparticles have the potential to facilitate tau tangle clearance, promote synaptic integrity, and prevent excessive neuronal apoptosis. Further research into tau-targeting nanoparticles …

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Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages

BTO NPs-mediated piezoelectric stimulation effectively induced macrophage M2 polarization and metabolic reprogramming, represented by enhanced TCA cycle and one-carbon folate cycle. After that, anti-inflammatory and pro-differentiation M2 promoted osteogenic differentiation of bone marrow mesenchymal stem cells. The osteo-friendly immune microenvironment formed by piezoelectric stimulation effectively promoted the regeneration of alveolar bone defects. Abstract: Immunomodulation has …

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Advanced electrocatalysts for fuel cells: Evolution of active sites and synergistic properties of catalysts and carrier materials

This review describes the evolution of active sites and synergistic properties of catalysts and support materials. In terms of precious metal catalysts, the effects of coordination and synergistic effects, phase structure, crystal surface engineering, and lattice strain were introduced. In non-precious metal catalysts, carbon-based and M-N-C electrocatalysts are introduced. Special emphasis is placed on the …

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Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases

Microporous ZIF-67 is synthesized in situ on the 3D interconnected network of bamboo cellulose fibers to produce a multiscale porous filter with a comprehensive pore size distribution. The porous filter has an excellent filtration effect on the particles particulate matter (PM, including PM10, PM2.5 and PM0.3) and harmful gas molecules in the air. Abstract: Air …

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Harnessing stimuli-responsive biomaterials for advanced biomedical applications

The application of physical stimulation biomaterials based on ultrasound, light, electricity, and magnetism in the field of biomedicine is summarized, as electrical stimulation of nerve regeneration, electrical stimulation of skin regeneration, electrical stimulation of bone regeneration, photothermal/photodynamic, ultrasound stimulated tissue repair, ultrasonic controlled release, targeting/controlled release, magnetic stimulation tissue repair. Abstract: Cell behavior is intricately …

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Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Within this review, an in-depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune-mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs. Furthermore, the review delves into the …

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Advancements and challenges in brain cancer therapeutics

The review summarizes various treatment options for brain tumors, focusing on their mechanisms, potential side effects, and recent developments. It emphasizes the need for personalized, multi-modal treatment approaches in this rapidly evolving field, balancing efficacy and patient safety. The complexity and diversity of brain tumor treatments are highlighted, advocating for ongoing research and technological advancements …

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Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer

Herein, a photothermal nanoplatform based on ferric ions (Fe3+), naturally-derived polyphenol gallic acid (GA), model antigen ovalbumin (OVA), and l-buthionine sulfoximine (BSO) was constructed, which can supply with GPX4 inhibitors to eliminate colorectal cancer (CRC) by trapping the tumor cells in the ferroptosis and immunotherapy cascade loop. This strategy provides a promising approach to significantly …

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Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches

The readout circuit based on inkjet-printed deep-subthreshold operated thin film transistors (TFTs) based on amorphous indium-gallium-zinc oxide (a-IGZO) successfully digitalizes analog sensor data and provides easy-to-detect visual identification of the sensor signal at a preset threshold crossover using high-current oxide TFTs. Notably, the complete smart sensor patch is shown to operate at a low voltage …

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High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption

Matrix-free solid-state RTP with an average lifetime of 0.50 s is realized in the carbon dots (CDs) synthesized by the one-pot hydrothermal process of powder made of feather wastes. The room-temperature phosphorescence lifetime is further prolonged to 1.97 s by employing polyvinyl alcohol (PVA) and phytic acid (PA). Subsequently, a novel CDs/PVA/PA ink is successfully …

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