the Author

Tumor cell membrane-based vaccines: A potential boost for cancer immunotherapy

The review provides a comprehensive overview of the development and application of tumor cell membrane (TCM)-based vaccines for cancer protection and therapy. A detailed description of structure of the TCM-wrapped particles (TCMPs), modification of TCMPs, membrane hybridization, and related adjuvants is given. As a derivative of TCM, the vaccines for tumor-derived-extracellular vesicles (TEVs) are also …

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Long non-coding RNA CASC15 enhances learning and memory in mice by promoting synaptic plasticity in hippocampal neurons

There is an increasing body of evidence suggesting the involvement of long non-coding RNAs (lncRNAs) in neural development and function. Nevertheless, the relationship between lncRNAs and Alzheimer’s disease (AD) remains uncertain. Previous genome-wide association studies (GWAS) have linked cancer susceptibility candidate 15 (CASC15) with AD. This study aims to comprehensively investigate the characteristics and mechanisms …

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Emerging nitric oxide gas-assisted cancer photothermal treatment

A comprehensive review summarizes recent advancements in nitric oxide (NO) gas-assisted cancer photothermal treatment. It commences by providing various types of NO donors/precursors for dual-modal therapy. Subsequently, chemotherapy, photodynamic therapy, alkyl radical therapy, radiation therapy, immunotherapy, chemodynamic therapy, starvation therapy, Ca2+ overload, and ferroptosis are incorporated for triple- and tetra-modal treatment. Abstract: Photothermal therapy (PTT) …

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Metal-based smart nanosystems in cancer immunotherapy

Metal-based smart nanosystems show great potential in modulating each phase of the cancer immunity cycle to boost anticancer immune responses against tumor growth, recurrence, and metastasis mainly by inducing immunogenic cell death, repolarizing protumoral M2 tumor associated macrophages(TAMs) into antitumoral M1 phenotype, and activating the cGAS-STING signaling pathway. Abstract: Metals are an emerging topic in …

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Innovative utilization of cell membrane-coated nanoparticles in precision cancer therapy

Cell membrane-coated nanoparticles (CMNPs) have recently emerged as a promising platform for cancer therapy. This review provides a comprehensive overview of the recent advancements in utilizing CMNPs as effective drug delivery vehicles for cancer therapy, including synthesis methods, functionalization strategies, preclinical studies utilizing CMNPs for cancer therapy, and future directions and challenges of clinical potential …

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Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration

This study aims to understand ATP synthase inhibitory factor 1’s (ATPIF1’s) role in peripheral nerve regeneration (PNR) using a murine model of sciatic nerve crush injury. Histological exams and behavior assessments revealed ATPIF1 absence hindered nerve tissue reconstruction, delaying sensory and functional recovery. RNA-sequencing showed reduced immune responses in ATPIF1 knockout mice, particularly CCR2/CCL2 signaling-mediated …

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Deformable nanocarriers for enhanced drug delivery and cancer therapy

Deformable nanocarriers with various morphological transformations for diferent potential applications. Abstract: Recently, the field of nanomedicine has witnessed substantial advancements in the development of nanocarriers for targeted drug delivery, emerges as promising platforms to enhance therapeutic efficacy and minimize adverse effects associated with conventional chemotherapy. Notably, deformable nanocarriers have garnered considerable attention due to their …

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Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform

The current monitoring technologies for biological loads in sewage exhibit drawbacks, including low detection efficiency and insufficient accuracy. The authors’ research team has developed an innovative approach that harnesses the power of the CRISPR/Cas12a system within an automated robot-driven photoelectrochemical biosensing platform. This platform allows early detection and tracking of infectious disease outbreaks, providing timely …

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Conducting polymer hydrogels based on supramolecular strategies for wearable sensors

This review summarizes typical supramolecular strategies for developing high-performance conducting polymer hydrogels (CPHs) and elucidates their properties relevant to wearable sensors. Additionally, it discusses the fabrication methods and classification of supramolecular CPH sensors and their latest applications in wearable devices. Finally, the review addresses these sensors’ challenges and provides suggestions for future developments. Abstract: Conductive …

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Motorizing the buckled blister for rotary actuation

We explore the rotation of a buckled blister constrained inside an outer ring. The rotation of buckled blister iss actuated via a localized change of curvature, and lower energy-supply is required to initiate the snap-through of buckling compared to conventional bistable mechanism. We experimentally demonstrate the controllability in rotational speed and output torque for a bimetallic …

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