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Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics

Engineered cancer cell membranes (ECCMs) including hybrid CCMs and functionalized CCMs have offered increasing possibilities in the field of cancer theranostics. This review summarizes the recent advances in the development of ECCMs for different biomedical applications, in particular for targeted drug delivery, immunity induction, and circulating tumor cell capture and detection. Abstract: For efficient cancer …

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Tumor hijacks macrophages and microbiota through extracellular vesicles

Tumor-derived extracellular vesicles can carry malignant factors from tumor cells and help hijack macrophages and microbiota in the tumor microenvironment (TME). In turn, the hijacked macrophages and microbiota can respond with tumor-promoting feedback, achieving a reciprocal coexistence in the TME and working together to facilitate tumor progression. Abstract: The tumor microenvironment (TME) is a biological …

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Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects

Mimicking the dynamic ligand presentation in extracellular matrix is crucial to advanced biomaterial design. This review summarizes currently developed dynamic biomaterial interfaces with reversible display of ligands through different molecular strategies. The paradigmatic examples for each strategy as well as their applications in cell regulation are highlighted. Abstract: The extracellular matrix (ECM) provides not only …

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Highly branched amylopectin binder for sulfur cathodes with enhanced performance and longevity

Inspired by the extraordinarily resilient and strong binding force of the Great Wall binder, that is, the sticky rice mortar, we extracted highly branched amylopectin, the effective ingredient, as a low-cost, nontoxic, and environmentally benign aqueous binder for high performance and long life sulfur cathode. Abstract: The sulfur cathode of lithium-sulfur (Li-S) batteries suffers from …

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Molecular dynamics simulation‐guided toehold mediated strand displacement probe for single‐nucleotide variants detection

This work provides mechanistic insights into toehold-mediated strand displacement process at the single-nucleotide level through molecular dynamics simulation. Mismatches at the border of the toehold and branch migration domain yield the lowest reaction rate. Based on the simulation results, single nucleotide variants of disease-related genes were detected with high specificity. Abstract: Single nucleotide variant (SNV) …

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Recent progress in self-powered multifunctional e-skin for advanced applications

In this review, we compile the latest work of self-powered multifunction e-skin, discussing related energy sources and coupling techniques. In addition, the latest progress of multifunctional self-powered e-skin for applications in physiological health, human–machine interaction (HMI), virtual reality (VR), and artificial intelligence (AI) are also present. Abstract: Electronic skin (e-skin), new generation of flexible wearable …

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Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases

This review summarized the advantages and challenges of nanotechnology-based mitochondrial-targeted therapy for neurodegenerative diseases (NDs). In this review, relationships between mitochondrial dysfunction and NDs are discussed; the applications of various NPs in treatment and diagnosis of mitochondrial dysfunction related NDs are also introduced. Abstract: Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes …

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Ultrasound-controlled drug release and drug activation for cancer therapy

This review presents a comprehensive summary of the current understanding of ultrasound-sensitive drug delivery systems for controlled drug release and drug activation. The typical mechanisms and the main factors affecting the ultrasonic responsiveness of drug carriers are summarized. Representative examples of ultrasound-controlled drug release and drug activation are highlighted. Abstract: Traditional chemotherapy suffers from severe …

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Exploring new battery knowledge by advanced characterizing technologies

Advanced characterizing technologies are of critical importance in enabling the revealing of materials regarding their structural and chemical information, eventually establishing the correlations between microstructures and properties at the multiscale levels. Abstract: Exploration of science and technologies represents human’s thirst for new knowledge and new life. Presently, we are in a stage of transferring the …

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Schiff-bases for sustainable battery and supercapacitor electrodes

A Schiff-base reaction is a condensation reaction between amine and carbonyl groups. It can be used to synthesize various organic materials. The precursors are often low-cost, and the synthesis utilizes mild conditions without the use of toxic chemicals. Therefore, these materials gained significant attention for sustainable electrodes. In this review, we discuss their applicability for …

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