Development of novel ionizable lipid and realization of real-time payload visualization are of great importance for siRNA delivery and clinical translation. Herein, we fabricated multifunctional ionizable iLNPs based on a newly prepared lipid for targeted delivery of siRNA and MRI contrast agent, which achieved good siRNA transportation, well imaging effect and excellent therapeutic outcome in …
A novel supramolecular dendrimeric nanosystem carrying the anticancer drug doxorubicin was developed in this study. We demonstrated this nanosystem markedly overcoming the heterogeneity of drug response and resistance of primary cultured tumor cells derived from 35 PDAC patients. This simple and convenient dendrimer nanodrug holds great promise as a potential candidate to treat the deadly …
Biological applications of nanomaterials as delivery carriers have been embedded in traditional biomedical research for decades. Despite lagging behind, recent significant breakthroughs in the use of nanocarriers as tools for plant biotechnology have created great interest.
