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Methodological advances of bioanalysis and biochemical targeting of intracellular G-quadruplexes

G-quadruplexes involve in various biological processes in living cells, and are considered as a promising new target for disease therapeutics, but the detailed mechanism of G4 biofunction remains elusive. This review highlights recent methodological advances about intracellular G-quadruplexes and provides an outlook on the improvement of the bioanalysis and biochemical targeting tools of G-quadruplexes. Abstract: …

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Harnessing anti-tumor and tumor-tropism functions of macrophages via nanotechnology for tumor immunotherapy

Modulating macrophages for tumor immunotherapy holds great promise to improve anti-tumor efficacy. Inhibition of macrophage recruitment, depleting tumor-associated macrophages (TAMs), repolarizing TAMs, and regulating macrophage-mediated phagocytosis of tumor cells are the four major strategies for manipulating macrophage-mediated tumor immunotherapy. Abstract: Reprogramming the immunosuppressive tumor microenvironment by modulating macrophages holds great promise in tumor immunotherapy. As …

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Rational design of allosteric switchable catalysts

Allosteric regulation controls the activities of natural enzymes and expands the chemical biology toolbox for the research on switchable catalysts. These rationally designed substitutes for unstable natural enzymes have been applied in areas such as biosensors and biomimetic cascade reactions. This review extended the concept of allosterism to artificial scaffolds and introduced a variety of …

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Organic fluorescent nanoprobes with NIR-IIb characteristics for deep learning

This paper reviews the recent progresses of organic fluorescent nanoprobes (OFNPs) with NIR-IIb emission, focusing on their construction strategies, optical properties, and their applications in deep learning in small animal models such as cerebrovascular imaging, tumor imaging, intestinal imaging, and systemic vascular imaging. In addition, the challenges and potential future research based on NIR-IIb fluorescent …

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Electrolyte formulation strategies for potassium-based batteries

This review mainly focuses on the recent progress of various liquid organic and solid-state K+ electrolytes for potassium-based batteries. First, the key design principles and applications of organic liquid electrolyte in various battery systems are discussed. Then the research status of ionic liquid, gel/polymer, and solid electrolyte are summarized and evaluated. Finally, this review discusses the …

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Emerging polymeric electrospun fibers: From structural diversity to application in flexible bioelectronics and tissue engineering

Electrospinning (e-spin) technique has emerged as a versatile and feasible pathway for constructing polymeric fabric with structural diversity, which show potential applications in flexible bioelectronics and tissue engineering for the sensing and therapeutic purposes. This perspective focus on the fabrication strategies of hierarchically structured e-spin fibers as well as the most cutting-edge progress in these …

Emerging polymeric electrospun fibers: From structural diversity to application in flexible bioelectronics and tissue engineering Read More »

Exploration of nanozymes in viral diagnosis and therapy

The various catalytic activities of the nanoparticles and their applications in diagnosing and treating viral diseases and their advantages. Abstract: Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared with natural enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, the synthesis of …

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Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics

Engineered cancer cell membranes (ECCMs) including hybrid CCMs and functionalized CCMs have offered increasing possibilities in the field of cancer theranostics. This review summarizes the recent advances in the development of ECCMs for different biomedical applications, in particular for targeted drug delivery, immunity induction, and circulating tumor cell capture and detection. Abstract: For efficient cancer …

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Tumor hijacks macrophages and microbiota through extracellular vesicles

Tumor-derived extracellular vesicles can carry malignant factors from tumor cells and help hijack macrophages and microbiota in the tumor microenvironment (TME). In turn, the hijacked macrophages and microbiota can respond with tumor-promoting feedback, achieving a reciprocal coexistence in the TME and working together to facilitate tumor progression. Abstract: The tumor microenvironment (TME) is a biological …

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Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects

Mimicking the dynamic ligand presentation in extracellular matrix is crucial to advanced biomaterial design. This review summarizes currently developed dynamic biomaterial interfaces with reversible display of ligands through different molecular strategies. The paradigmatic examples for each strategy as well as their applications in cell regulation are highlighted. Abstract: The extracellular matrix (ECM) provides not only …

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