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A red blood cell-derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery

This research develops an “all-in-one” red blood cell-derived microrobot capable of stably circulating in blood vessels, targeting tumour regions under magnetic guidance, releasing therapeutic cargoes upon laser trigger, and facilitating drug penetration by damaging extracellular matrix in tumour tissues. This system addresses critical challenges during systemic drug delivery and represents a new class of intelligent …

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Advances in the treatment of atherosclerosis with ligand-modified nanocarriers

Overview diagram of targeted ligand-modified nanomedicines for the treatment of atherosclerosis. Ligand-modified nanoparticles targeting specific atherosclerosis receptors at each pathological stage from monocyte recruitment, macrophage polarisation and foam cell formation, vascular smooth muscle cell phenotypic transformation, and vulnerable plaque formation, opening up ideas for the design of atherosclerosis-targeted nanomedicines. Abstract: Atherosclerosis, a chronic disease associated …

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Cold atmospheric plasma can effectively disinfect SARS-CoV-2 in the wastewater

Cold atmospheric plasma can produce peroxynitrite (ONOO−), ozone (O3), superoxide anion radicals (O2−), and hydrogen peroxide (H2O2) as the major reactive species to inactivate coronaviruses by disrupting the viral Spike protein and genomic RNA, thus hindering viral entry and replication. This study highlights the potential of cold atmospheric plasma as a promising approach to combat …

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Cerebrospinal fluid efflux through dynamic paracellular pores on venules as a missing piece of the brain drainage system

A novel drainage pathway through which cerebrospinal fluid (CSF)/interstitial fluid (ISF) molecules enter the bloodstream directly via dynamically assembled trumpet-shaped pores on the walls of brain venules was discovered. An updated model for glymphatic clearance of brain metabolites and potential roles in the Alzheimer disease and some neurological disorders are discussed. Abstract: The glymphatic system …

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The dissolution, reassembly and further clearance of amyloid-β fibrils by tailor-designed dissociable nanosystem for Alzheimer’s disease therapy

A tailor-designed dissociable nanosystem can decompose into small nanostructures in brain microenvironment of Alzheimer’s disease, and then recognize and bind amyloid-β for the dissolution, reassembly and further clearance of amyloid-β fibrils. This nanosystem rescues cognitive and memory impairments in mice for Alzheimer’s disease therapy. Abstract: The fibrillation of amyloid-β (Aβ) is the critical causal factor …

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Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling

The ion cocktail, consisting of silicate, strontium and copper could attenuate both electrical and structural remodeling after myocardial infarction in rat and Bama minipigs. The therapeutic effect of ion cocktail on myocardial infarction may account for that different ions in the cocktail have different functions to regulate cellular behaviors. Abstract: Myocardial infarction (MI) is a …

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Tumour-microenvironment-responsive Na2S2O8 nanocrystals encapsulated in hollow organosilica–metal–phenolic networks for cycling persistent tumour-dynamic therapy

Traditional tumour-dynamic therapy still inevitably faces the critical challenge of limited reative oxygen species (ROS)-generating efficiency due to tumour hypoxia, strict Fenton reaction conditions, and un-sustainable mono-catalytic reaction. To fight against these issues, a tumour–microenvironment-responsive yolk–shell nanoreactor is developed to realize the high-efficiency, selective, and sustainable dynamic therapy via cascade-responsive dual cycling amplification of •SO4−/•OH …

Tumour-microenvironment-responsive Na2S2O8 nanocrystals encapsulated in hollow organosilica–metal–phenolic networks for cycling persistent tumour-dynamic therapy Read More »

Recent advancements in implantable neural links based on organic synaptic transistors

Rapid advancement in brain synaptic devices uses field effect transistors to simulate human brain synapses. Organic semiconductors, which are noted for their simplicity and biocompatibility, have enormous potential in brain synaptic bioelectronics. This review discusses ongoing obstacles, even with employment in integrated circuits and brain networks, and covers recent improvements, their application, and future research …

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Advanced membrane-based electrode engineering toward efficient and durable water electrolysis and cost-effective seawater electrolysis in membrane electrolyzers

This review summarizes the cutting-edge electrode engineering strategies, including electrode structure engineering, interface engineering, catalyst utilization improvement, electrode reaction environment regulation, cell-voltage-breakdown strategy, and so on toward the most promising commercialized, near-commercialized, and advanced membrane water electrolyzer technologies, aiming to achieve efficient, durable, and economical green hydrogen production through water electrolysis. Abstract: Researchers have been …

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Unveiling of a puzzling dual ionic migration in lead- and iodide-deficient halide perovskites (d-HPs) and its impact on solar cell J–V curve hysteresis

In the present paper, a phenomenon of ionic migration of large organic cations in the lead- and iodide-deficient perovskite films is unveiled. This phenomenon is intrinsic to the structure and at the origin of a large hysteresis in the measured J–V curves. Contrary to iodide, it cannot be fully blocked through defect passivation by potassium …

Unveiling of a puzzling dual ionic migration in lead- and iodide-deficient halide perovskites (d-HPs) and its impact on solar cell J–V curve hysteresis Read More »