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This study investigates the effect of protein properties on the nanomaterial-protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo-like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the BPNMs. Notably, BPNMs specifically bind to PLK1, while …

Target Binding of Black Phosphorus Nanomaterial to Polo-Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein Read More »

NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL-1β and TNF-α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation via the continuous activation of K375 site in …

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis: Modulating Crotonylation in Ulcerative Colitis Read More »

This study demonstrates that elevated N-acetyltransferase 10 (NAT10) expression stabilizes SMAD3 mRNA through ac4C modification, promoting the progression of hepatocellular carcinoma (HCC). NAT10 also activates the TGF-β signaling pathway, facilitating epithelial-to-mesenchymal transition and inhibiting anoikis. Furthermore, the authors develop a small-molecule inhibitor, NAT10-2023, which disrupts NAT10’s interaction with RNA, reducing ac4C modification levels and suppressing HCC …

Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C-Mediated SMAD3 mRNA Stability Read More »

To effectively alleviate the severe shuttle effect and delayed redox kinetics of lithium–sulfur batteries, CoWO4−x/CNT composites with different oxygen vacancy concentrations were prepared. The p–d orbital hybridization caused by oxygen vacancy enhances the bidirectional sulfur conversion, and provides valuable insights for the development of highly active catalysts for lithium–sulfur batteries. Abstract: Lithium–sulfur batteries (LSBs) have …

Enhancing Bidirectional Sulfur Conversion Through p–d Orbital Hybridization via Vacancy Engineering Read More »

The engineered bacteria (2’3′-cGAMP@E.coli) is designed to synthesize intracellular 2’3′-cGAMP, enabling the assembly of personalized nanovaccines (nECTs) through a bioconjugation with autologous tumor antigens, circumventing elaborate chemical production processes. The therapeutic impact of nECTs is significantly amplified when combined with a fasting-mimicking diet, illustrating the potent synergies of this integrated therapeutic approach. Abstract: Cyclic dinucleotides, …

Personalized Cancer Immunotherapy Boosted by cGAS-STING-Targeted Nanovaccines in Combination With Nutrient Modulation Read More »

Amphibian-derived peptide RL-QN15 activates the Wnt/β-catenin signaling pathway by interacting with the FZD8 membrane receptor, promoting epidermal stem cells proliferation, migration, stemness, and EMT processes, thus promoting skin wound healing. Abstract: The pursuit of developing groundbreaking pro-regenerative therapies to expedite skin wound healing persists as a formidable challenge. Peptide RL-QN15, emerges as a highly promising …

Peptide RL-QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β-Catenin Axis Read More »

Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR-related mRNA at the 5′ ss and 3′ ss, generating two mature mRNA isoforms, which are ultimately translated into CSR-related proteins. These CSR-related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, …

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells Read More »

The developed SnS2 nanostrctures with three morphology of stacked nanosheets, microspheresand microflowers exhibit the excellent SERS enhanced uniformity, generality, stability and ultra-high sensitivity, which are expected to provide a class of potential commercial SERS-active materials for the practical application of semiconductor-based SERS technology. Abstract: Recent advances indicate the surface-enhanced Raman scattering (SERS) sensitivity of semiconductors …

Morphology Engineering of SnS2 Nanostructures to Stimulate PICT Resonance for Ultra-Sensitive SERS Sensors Read More »