the Author

Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications

Article, Research Article / By

A mussel-inspired self-assembly strategy is proposed to fabricate silver aerogels based on ultrasmall silver nanoclusters through a dopamine-assisted gelation process. The fabricated silver aerogels possess excellent catalytic and antibacterial properties owing to the synergistic effect of silver nanoclusters and polydopamine, which holds promising potential as novel multifunctional materials for application in environmental and healthcare fields. …

Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications Read More »

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages

Article, Research Article / By

High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors leading to the resistance of glioma to immunotherapy. This study constructed engineering MSCs expressing IL-12 and nCD47-SLAMF7 (anti-CD47 nanobody combined with the extracellular domain of SLAMF7). Intracranial injection of these two kinds of …

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages Read More »

Tau-targeting nanoparticles for treatment of Alzheimer’s disease

Article, Review Article / By

Through review of comprehensive literature and research studies, it is found that tau-targeting nanoparticles may posit beneficial applications to AD therapy. By targeting a key molecular mechanism known to propagate AD pathogenesis, tau-targeting nanoparticles have the potential to facilitate tau tangle clearance, promote synaptic integrity, and prevent excessive neuronal apoptosis. Further research into tau-targeting nanoparticles …

Tau-targeting nanoparticles for treatment of Alzheimer’s disease Read More »

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages

Article, Research Article / By

BTO NPs-mediated piezoelectric stimulation effectively induced macrophage M2 polarization and metabolic reprogramming, represented by enhanced TCA cycle and one-carbon folate cycle. After that, anti-inflammatory and pro-differentiation M2 promoted osteogenic differentiation of bone marrow mesenchymal stem cells. The osteo-friendly immune microenvironment formed by piezoelectric stimulation effectively promoted the regeneration of alveolar bone defects. Abstract: Immunomodulation has …

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages Read More »

Advanced electrocatalysts for fuel cells: Evolution of active sites and synergistic properties of catalysts and carrier materials

Article, Review Article / By

This review describes the evolution of active sites and synergistic properties of catalysts and support materials. In terms of precious metal catalysts, the effects of coordination and synergistic effects, phase structure, crystal surface engineering, and lattice strain were introduced. In non-precious metal catalysts, carbon-based and M-N-C electrocatalysts are introduced. Special emphasis is placed on the …

Advanced electrocatalysts for fuel cells: Evolution of active sites and synergistic properties of catalysts and carrier materials Read More »

Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases

Article, Research Article / By

Microporous ZIF-67 is synthesized in situ on the 3D interconnected network of bamboo cellulose fibers to produce a multiscale porous filter with a comprehensive pore size distribution. The porous filter has an excellent filtration effect on the particles particulate matter (PM, including PM10, PM2.5 and PM0.3) and harmful gas molecules in the air. Abstract: Air …

Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases Read More »

Harnessing stimuli-responsive biomaterials for advanced biomedical applications

Article, Review Article / By

The application of physical stimulation biomaterials based on ultrasound, light, electricity, and magnetism in the field of biomedicine is summarized, as electrical stimulation of nerve regeneration, electrical stimulation of skin regeneration, electrical stimulation of bone regeneration, photothermal/photodynamic, ultrasound stimulated tissue repair, ultrasonic controlled release, targeting/controlled release, magnetic stimulation tissue repair. Abstract: Cell behavior is intricately …

Harnessing stimuli-responsive biomaterials for advanced biomedical applications Read More »

Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Article, Review Article / By

Within this review, an in-depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune-mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs. Furthermore, the review delves into the …

Exploring precision treatments in immune-mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery Read More »

Advancements and challenges in brain cancer therapeutics

Article, Review Article / By

The review summarizes various treatment options for brain tumors, focusing on their mechanisms, potential side effects, and recent developments. It emphasizes the need for personalized, multi-modal treatment approaches in this rapidly evolving field, balancing efficacy and patient safety. The complexity and diversity of brain tumor treatments are highlighted, advocating for ongoing research and technological advancements …

Advancements and challenges in brain cancer therapeutics Read More »

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer

Article, Research Article / By

Herein, a photothermal nanoplatform based on ferric ions (Fe3+), naturally-derived polyphenol gallic acid (GA), model antigen ovalbumin (OVA), and l-buthionine sulfoximine (BSO) was constructed, which can supply with GPX4 inhibitors to eliminate colorectal cancer (CRC) by trapping the tumor cells in the ferroptosis and immunotherapy cascade loop. This strategy provides a promising approach to significantly …

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer Read More »