Article

A review of Mpox: Biological characteristics, epidemiology, clinical features, diagnosis, treatment, and prevention strategies

Article, Review Article / By

The monkeypox virus (MPXV) has spread to many countries and caused thousands of infections all over the world. This review comprehensively introduces the biology, epidemiological characteristics of MPXV, and clinical manifestations of Mpox. The approaches for diagnosis, treatment, and prevention are also introduced, aiming to improve the general comprehension of Mpox. Abstract: The outbreak of …

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Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED

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For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) is used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesize an all-inorganic lead-free yellow light CsCu2I3 powder in water. The stable and efficient CsCu2I3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields. Abstract: Yellow light-emitting …

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Antigen/adjuvant-free liposome induces adjuvant effects for enhancing cancer immunotherapy

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In this study, the authors have developed a library of antigen/adjuvant-free liposomes for testing the adjuvant effects. The anionic liposomes with appropriate surface charges enhance host immunity by regulating the Th1, Th2 and CD8+ T cells in lymphoid organs with good safety. It shows efficient therapy against MC38 colorectal cancer when combined with tumor antigens. …

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Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood-brain barrier

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The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood-brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels. The meningeal lymphatic system and glymphatic …

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A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway

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In this research, a nanoparticle formulation, Parthenolide/ICG-CaCO3@Lipid (PTL/ICG-CaCO3@Lip), has been engineered to amplify ferroptosis in tumor cells, positioning it as a potent agent for sonodynamic cancer immunotherapy. This nanoparticle significantly augments ROS levels within tumor cells, inducing oxidative stress, and regulating P53 to downregulate SLC7A11 protein expression, thereby inhibiting the glutamate-cystine antiporter system Xc- and …

A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway Read More »

Well-defined nanostructures of high entropy alloys for electrocatalysis

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This paper summarizes and discusses the synthetic methods used to obtain well-defined HEAs nanostructures (0D nanoparticles, 1D nanowires, 2D nanosheets/nanoplates, 3D nanoporous structures, and other 3D morphologies) for the applications in several typical electrocatalytic reactions, including hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, alcohol oxidation reaction, carbon dioxide reduction reaction, nitrogen reduction reaction, …

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Wash-free fluorescent tools based on organic molecules: Design principles and biomedical applications

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In this review, the design principles for wash-free molecular fluorescent tools are highlighted in four diverse details. Meanwhile, biomedical applications including wash-free fluorescent imaging of organelles, cellular microenvironment, biomacromolecules, and small species, as well as therapy and potential drug delivery, are also emphasized. This review may bring wash-free molecular fluorescent tools to the forefront, as …

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Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma

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An acid-cleavable Tf-modified engineering exosome-based brain-targeting delivery system (ACTE) was proposed using metabolic glycoengineering and bioorthogonal click chemistry, enabling co-delivery of siTGF-β and DOX for GBM treatment. ACTE was featured by higher BBB transcytosis efficiency and hierarchical targeting delivery to GBM cells. Ds@ACTE effectively reprogrammed the immunosuppressive GBM microenvironment, reducing chemoresistance and enhancing anti-GBM immune …

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Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications

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A mussel-inspired self-assembly strategy is proposed to fabricate silver aerogels based on ultrasmall silver nanoclusters through a dopamine-assisted gelation process. The fabricated silver aerogels possess excellent catalytic and antibacterial properties owing to the synergistic effect of silver nanoclusters and polydopamine, which holds promising potential as novel multifunctional materials for application in environmental and healthcare fields. …

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Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages

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High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors leading to the resistance of glioma to immunotherapy. This study constructed engineering MSCs expressing IL-12 and nCD47-SLAMF7 (anti-CD47 nanobody combined with the extracellular domain of SLAMF7). Intracranial injection of these two kinds of …

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages Read More »