Article

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells

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Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR-related mRNA at the 5′ ss and 3′ ss, generating two mature mRNA isoforms, which are ultimately translated into CSR-related proteins. These CSR-related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, …

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Morphology Engineering of SnS2 Nanostructures to Stimulate PICT Resonance for Ultra-Sensitive SERS Sensors

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The developed SnS2 nanostrctures with three morphology of stacked nanosheets, microspheresand microflowers exhibit the excellent SERS enhanced uniformity, generality, stability and ultra-high sensitivity, which are expected to provide a class of potential commercial SERS-active materials for the practical application of semiconductor-based SERS technology. Abstract: Recent advances indicate the surface-enhanced Raman scattering (SERS) sensitivity of semiconductors …

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Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies

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Schematic illustration of structural and functional biomimicry. The upper part shows BP with various structures such as monolayered, surface-microstructural, bilayered and multilayered. The bottom part exhibits BP with different functions including immune regulation, drugs/cells/factors/ions loading, as well as bioelectrical stimulation and neuroregulation. Abstract: The periosteum is crucial in the processes of bone formation, regeneration, and …

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Metal Nitride Catalysts for Photoelectrochemical and Electrochemical Catalysis

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Metal nitrides exhibit excellent electrical conductivity and catalytic activity, making them promising for (photo)electrochemical reactions. This review explores their electronic structure, surface chemistry, and synthesis strategies, emphasizing morphology and phase control. Detailed discussions on catalyst designs for hydrogen/oxygen evolution, oxygen/nitrogen/carbon dioxide reduction, and biomass valorization reactions provide significant insights for optimizing performance. Abstract: Metal nitrides …

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Understanding the Engineering Tactics to Achieve the Stabilized Anode in Next-Generation Zn-Air Batteries

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This review highlights crucial design strategies for zinc anodes and significant electrolyte modifications to address key challenges in zinc-air battery development. The article is intended to serve as a valuable resource for a broad audience, from novice researchers to industry professionals, guiding the development of Zn-air batteries. Abstract: The modern technical era demands sustainable and …

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Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

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We identified a harmful immune cell type, p21+CD86+ microglia, driving post-stroke inflammation and developed a targeted exosome-based therapy (Que@micro-Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other central nervous system disorders. Abstract: Stroke remains the leading cause of …

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Recent Advancements in Ambient-Air Fabrication of Perovskite Solar Cells

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This review discusses design principles, preparaThis review explores the fabrication of perovskite solar cells (PSCs) in ambient air, highlighting strategies to enhance their stability and performance. It discusses challenges such as degradation under environmental conditions and outlines methods for large-scale manufacturing, offering insights into the commercialization and future development of PSC technology for sustainable energy …

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Design Principles Of Inorganic-Protein Hybrid Materials for Biomedicine

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Inorganic protein hybrid materials (IPHMs) due to editable structure present unrivalled potential at the intersection of synthetic biology and materials science. The synthesis of IPHMs with a high degree of biosafety from bioactive units represents a shift in material design and synthesis. This paper focuses on a review of the structural basis and design principles …

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Applications and Challenges of Auditory Brain-Computer Interfaces in Objective Auditory Assessments for Pediatric Cochlear Implants

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Auditory brain-computer interface connects the brain with external devices and decodes neural signals related to auditory perception. Time-domain and frequency-domain analyses are commonly used to identify biomarkers associated with auditory rehabilitation, such as cortical auditory evoked potentials and mismatch negativity. Additionally, source and functional connectivity analyses are employed to elucidate the process of auditory function …

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Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts

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Multifunctional and reusable PHC wound dressing was designed for accelerating movable wound healing process. With alternated NIR light irradiation, PHC can produce abundant heat and ROS for bacteria inactivation due to its photothermal and pyroelectric property. With the frequent movement of movable wound, PHC can effectively promote cell migration and proliferation due to its piezoelectric …

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