Article

Biomaterials and nanomedicine for bone regeneration: Progress and future prospects

Article, Perspective / By

We present an overview of common causes of bone defects, the unmet clinical needs, and the utility of biomaterials and nanotechnology to facilitate bone regeneration. Besides, we propose several key approaches to improve bone repair strategies. This perspective provides a guidance for future research direction of bone repair to improve treatment efficiency in both clinical …

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Super-stable mineralization effect of layered double hydroxides for heavy metals: Application in soil remediation and perspective

Article, Perspective / By

Owing to the super-stable mineralization property, layered double hydroxides exhibited excellent performance in soil remediation contaminated by heavy metal ions, providing new strategies and insights into rational designing of amendments in other heavy metals pollution scenarios. Abstract: Agriculture soil plays a crucial role in sustainable development of human society. Unfortunately, soil quality is continuing degradation …

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Dynamically switchable magnetic resonance imaging contrast agents

Article, Perspective / By

This perspective highlights the recent development of dynamically switchable MRI contrast agents that can achieve structural transformation and controllable MR signal activation at the disease site in response to various pathological stimuli. Moreover, current challenges and future perspectives of dynamic contrast agents for the accurate detection of microscopic lesions are commented.

Self-powered technology based on nanogenerators for biomedical applications

Article, Review Article / By

With the continuous development of self-powered technology, self-powered biomedical electronic devices have attracted extensive attention due to their unprecedented advantages. Abstract: Biomedical electronic devices have enormous benefits for healthcare and quality of life. Still, the long-term working of those devices remains a great challenge due to the short life and large volume of conventional batteries. …

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Nanozyme for tumor therapy: Surface modification matters

Article, Review Article / By

The effects of surface modification on the antitumor activity of nanozymes are summarized in three ways: (1) directly or indirectly affecting the catalytic activity of nanozymes; (2) regulating the biodistribution of nanozymes; (3) alternating the intracellular fate of nanozymes. Abstract: As the next generation of artificial enzymes, nanozymes have shown unique properties compared to its …

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Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins

Article, Research Article / By

Bundled single-walled carbon nanotubes, as artificial neurotrophins, mediate dimerization and phosphorylation of tropomyosin-related kinase B, and stimulate downstream signaling pathways for neuronal survival and differentiation. These therapeutic effects alleviate EtOH-induced neurodegeneration in a rat model. Abstract: The distinguished properties of nanomaterials promote us to explore whether their intrinsic activities would be beneficial to disease treatment. …

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Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy

Article, Research Article / By

The therapeutic modality of “chemotherapy-augmented sequential chemoreactive therapy” based on the designed mitochondria-specific nanocatalyst composed of cisplatin prodrug and gallic acid-ferrous (GA-Fe(II)) nanocomposites achieves distinct catalytic cancer-therapeutic performance. The bioactive cisplatin elevates the endogenous H2O2 level through the cascaded reactions, and the GA-Fe(II) nanocomposites with sustainable Fenton catalytic activity subsequently catalyzes H2O2 into hydroxyl radicals …

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