Research Article

Our research reveals the spatial chromatin structural difference between colorectal cancer (CRC) cells and oxaliplatin resistant cells based on the DLO Hi-C and other epigenetic omics experiments. More importantly, we provide a series of A/B compartment switching genes as potential targets for oxaliplatin-resistant cancer treatment and find a new way to investigate drug resistance behavior …

Alteration of chromatin high-order conformation associated with oxaliplatin resistance acquisition in colorectal cancer cells Read More »

A novel 2D hydrogenated-silicon nanosheet (H-Si NSs) is integrated and functionalized into a β-tricalcium phosphate scaffold (H-Si TCP) for immuno-bone remodeling in our study. H-Si NSs has great ROS-responsive, immunoregulatory, and osteo-promotive property and H-Si TCP can provide sufficient ingredients and greatly improve bone regeneration step by step through osteoimmunomodulation-guided biodegradation in vivo. Abstract: An …

Hydrogenated silicene nanosheet functionalized scaffold enables immuno-bone remodeling Read More »

Great progress has been made in ingenious bone tissue engineering for osteonecrosis of the femoral head (ONFH) treatment in the last decades. In this review, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. We also propose insights on the current challenges of these advances in the clinic and the …

Mobile mechanical signal generator for macrophage polarization Read More »

We demonstrate a robust memcapacitor by stacking ferroelectric capacitor on the metal-insulator-semiconductor structure. It possesses a long retention time of more than 104 s and well endurance of 109 cycles. Ultralow-power in-memory computing based on ferroelectric memcapacitor array intrinsically consumes zero energy in memcapacitors themselves. It sheds light on an ultralow-power neural hardware based on ferroelectric memcapacitors. …

Ultralow-power in-memory computing based on ferroelectric memcapacitor network Read More »

Hippocampal Cntnap4 deficiency was associated with cognitive impairment via inducing pro-inflammatory response in females. A biomimetic microglial nanoparticle system (MNPs@PLX) was established for precise microglial delivery of FDA-approved PLX3397 to attenuate cognitive decline, dysfunctional synaptic plasticity, and pro-inflammatory response in female heterozygous Cntnap4 knockout mice. This study indicates that microglial supplementation of PLX3397 may serve as an intervention for …

Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency Read More »

Great progress has been made in ingenious bone tissue engineering for osteonecrosis of the femoral head (ONFH) treatment in the last decades. In this review, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. We also propose insights on the current challenges of these advances in the clinic and the …

Spatiotemporal single-cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage Read More »

Oxidative stress from reactive oxygen species (ROS) is a reperfusion injury factor that can lead to cell damage and death. Ultrasmall Fe-GA CPNs were synthesized to exert a protective role in ischemic brain neurons via removal of ROS, rescuing of glucose metabolism, and suppressing apoptosis through the upregulation of protein kinase B (Akt), antioxidant nuclear …

Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging-guided ischemia stroke therapy Read More »

A facile electric shock method is used to synthesize an efficient, stable, and inexpensive NiCoCuMoW bifunctional alloy electrocatalyst for both hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER). Combined experiments and theory calculations reveal that the multi-component synergy of different elements and plentiful active sites render the NiCoCuMoW superior HOR/HER performance, rivaling the Pt/C …

Electroshock synthesis of a bifunctional nonprecious multi-element alloy for alkaline hydrogen oxidation and evolution Read More »

This work describes the construction of bullet-shaped carbon hollow particles with controllable shell thicknesses by heterogeneous interface growth on hard template. As a near infrared light-propelled nanomotor, it shows higher diffusion coefficient and faster velocity by self-thermophoresis for the enhanced dye removal. Abstract: Materials with asymmetric nanostructures have attracted tremendous research attention due to their …

NIR light-propelled bullet-shaped carbon hollow nanomotors with controllable shell thickness for the enhanced dye removal Read More »

This paper demonstrates a novel active-ion-gated strategy to active the room temperature (RT) gas sensing performance of ZnO NWs by self-powered triboelectric plasma system in ambient environment. The activated ZnO NWs shows considerable sensitivity, excellent selectivity, and rapid response to acetone gas at RT with maximum power consumption only 4.5 mW. Abstract: Reducing the high operation …

Active-ion-gated room temperature acetone gas sensing of ZnO nanowires array Read More »