Research Article

For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) is used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesize an all-inorganic lead-free yellow light CsCu2I3 powder in water. The stable and efficient CsCu2I3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields. Abstract: Yellow light-emitting …

Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED Read More »

In this study, the authors have developed a library of antigen/adjuvant-free liposomes for testing the adjuvant effects. The anionic liposomes with appropriate surface charges enhance host immunity by regulating the Th1, Th2 and CD8+ T cells in lymphoid organs with good safety. It shows efficient therapy against MC38 colorectal cancer when combined with tumor antigens. …

Antigen/adjuvant-free liposome induces adjuvant effects for enhancing cancer immunotherapy Read More »

In this research, a nanoparticle formulation, Parthenolide/ICG-CaCO3@Lipid (PTL/ICG-CaCO3@Lip), has been engineered to amplify ferroptosis in tumor cells, positioning it as a potent agent for sonodynamic cancer immunotherapy. This nanoparticle significantly augments ROS levels within tumor cells, inducing oxidative stress, and regulating P53 to downregulate SLC7A11 protein expression, thereby inhibiting the glutamate-cystine antiporter system Xc- and …

A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway Read More »

An acid-cleavable Tf-modified engineering exosome-based brain-targeting delivery system (ACTE) was proposed using metabolic glycoengineering and bioorthogonal click chemistry, enabling co-delivery of siTGF-β and DOX for GBM treatment. ACTE was featured by higher BBB transcytosis efficiency and hierarchical targeting delivery to GBM cells. Ds@ACTE effectively reprogrammed the immunosuppressive GBM microenvironment, reducing chemoresistance and enhancing anti-GBM immune …

Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma Read More »

A mussel-inspired self-assembly strategy is proposed to fabricate silver aerogels based on ultrasmall silver nanoclusters through a dopamine-assisted gelation process. The fabricated silver aerogels possess excellent catalytic and antibacterial properties owing to the synergistic effect of silver nanoclusters and polydopamine, which holds promising potential as novel multifunctional materials for application in environmental and healthcare fields. …

Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications Read More »

High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors leading to the resistance of glioma to immunotherapy. This study constructed engineering MSCs expressing IL-12 and nCD47-SLAMF7 (anti-CD47 nanobody combined with the extracellular domain of SLAMF7). Intracranial injection of these two kinds of …

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages Read More »

BTO NPs-mediated piezoelectric stimulation effectively induced macrophage M2 polarization and metabolic reprogramming, represented by enhanced TCA cycle and one-carbon folate cycle. After that, anti-inflammatory and pro-differentiation M2 promoted osteogenic differentiation of bone marrow mesenchymal stem cells. The osteo-friendly immune microenvironment formed by piezoelectric stimulation effectively promoted the regeneration of alveolar bone defects. Abstract: Immunomodulation has …

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages Read More »

Microporous ZIF-67 is synthesized in situ on the 3D interconnected network of bamboo cellulose fibers to produce a multiscale porous filter with a comprehensive pore size distribution. The porous filter has an excellent filtration effect on the particles particulate matter (PM, including PM10, PM2.5 and PM0.3) and harmful gas molecules in the air. Abstract: Air …

Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases Read More »

Herein, a photothermal nanoplatform based on ferric ions (Fe3+), naturally-derived polyphenol gallic acid (GA), model antigen ovalbumin (OVA), and l-buthionine sulfoximine (BSO) was constructed, which can supply with GPX4 inhibitors to eliminate colorectal cancer (CRC) by trapping the tumor cells in the ferroptosis and immunotherapy cascade loop. This strategy provides a promising approach to significantly …

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer Read More »

The readout circuit based on inkjet-printed deep-subthreshold operated thin film transistors (TFTs) based on amorphous indium-gallium-zinc oxide (a-IGZO) successfully digitalizes analog sensor data and provides easy-to-detect visual identification of the sensor signal at a preset threshold crossover using high-current oxide TFTs. Notably, the complete smart sensor patch is shown to operate at a low voltage …

Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches Read More »