Research Article

Bioinspired copper single-atom nanozyme as a superoxide dismutase-like antioxidant for sepsis treatment

A SOD-inspired copper single-atom nanozyme (Cu-SAzyme) was designed and synthesized by a two-step scaffold-adsorption method. The Cu-SAzyme exhibits high catalytic activity to scavenge superoxide anion, the initiator of ROS, and thus effectively prevents the disease progression in septic animals. Abstract: Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection-caused …

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Nucleus-specific RNAi nanoplatform for targeted regulation of nuclear lncRNA function and effective cancer therapy

We herein developed a nucleus-specific RNAi nanoplatform for targeted regulation of nuclear lncRNA function and effective cancer therapy. This new RNAi nanoplatform could respond to the endosomal pH to expose NTPA/siRNA complexes for the nucleus-specific siRNA delivery, leading to a significant inhibition of nuclear lncNEAT2 expression and tumor growth of liver cancer. Abstract: In the …

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Atomic cerium modulated palladium nanoclusters exsolved ferrite catalysts for lean methane conversion

The CH4 conversion is of great environmental and industrial significance to solve the greenhouse effect. N2 as an optimal activation agent to develop a Pd nanocluster exsolved Ce-incorporated perovskite ferrite catalyst toward lean methane oxidation. The isolated Ce locating at the A-site of perovskite framework facilitates the thermodynamic and kinetics of the Pd exsolution process, lowering the …

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Cryopolymerization-enabled self-wrinkled polyaniline-based hydrogels for highly stretchable all-in-one supercapacitors

It is challenging to develop new preparation methods of conductive polymer-based composite hydrogels for constructing all-in-one supercapacitors (A-SCs) with excellent deformation-tolerant performance. Self-wrinkled polyaniline-based composite hydrogels (SPCHs) with large stretchability and excellent fatigue resistance are fabricated by a stretching/cryopolymerization/releasing strategy. The as-obtained SPCH can work as an intrinsically stretchable A-SC maintaining high energy density and …

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Gd2O3/b-TiO2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy

Low photoconversion efficiency and limited tissue penetration are the major barriers for photothermal therapy (PTT) agent application. Here, an efficient organic/inorganic dual-PTT agent guided by MRI was proposed. It is proved the oxygen vacancy band narrowed its band gap that led to NIR-II region absorb. Furthermore, the defect energy level trapping carrier and conjugate synergistic …

Gd2O3/b-TiO2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy Read More »

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy

Clinically approved indocyanine green (ICG) is utilized to develop simple prodrug nanoformulations. The ICG-driven assembly strategy endows paclitaxel prodrugs improved assembled behavior and enhanced colloidal stability, and the developed nanoparticles possess tumor-specific imaging and chemotherapy with in vivo therapeutic feedback. Abstract: Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. …

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Direct chemical editing of Gram-positive bacterial cell walls via an enzyme-catalyzed oxidative coupling reaction

This work describes a mild and efficient enzyme-catalyzed chemical reaction for the selective modification of Gram-positive bacterial cell walls. The as-designed technique can serve as a universal platform to functionalize the surfaces of live bacterial cells with diverse responsive materials, including small-molecule fluorescent dyes, horseradish peroxidase, and magnetic nanoparticles. Abstract: Chemically manipulating bacterial surface structures, …

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A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection

A dynamic covalent polymeric antimicrobial, based on phenylboronic acid-installed micellar nanocarriers incorporating vancomycin and curcumin, was developed to overcome drug-resistant bacterial infections. Compared with monotherapy, this antimicrobial displayed more significant eradication of drug-resistant bacteria in vitro and in vivo. This work could become a universal platform to combat the ever-threatening drug-resistant infectious diseases. Abstract: Increasing …

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Functional nucleic acid engineered double-barreled nanopores for measuring sodium to potassium ratio at single-cell level

Functional nucleic acid engineered double-barreled nanopores were designed and applied for measuring Na/K ratio (RNa/K) at single-cell level. The applicability of this nanotool is validated by practical probing intracellular RNa/K during the drug-induced primary stage of apoptotic volume decrease. Especially, the RNa/K has been shown by our nanotool to be different in cell lines with different metastatic …

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SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment

Examining the phenotypes of KRAS mutant and wild-type colorectal cancer cells during anti-EGFR treatment may provide significant insights into drug resistance. Herein, we applied surface-enhanced Raman spectroscopy (SERS) assay to detect four cell surface proteins on KRAS mutant and wild-type cells over a 24-day treatment, where SERS assay achieved multiplexed characterization of cell surface markers …

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