Research Article

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer

Herein, a photothermal nanoplatform based on ferric ions (Fe3+), naturally-derived polyphenol gallic acid (GA), model antigen ovalbumin (OVA), and l-buthionine sulfoximine (BSO) was constructed, which can supply with GPX4 inhibitors to eliminate colorectal cancer (CRC) by trapping the tumor cells in the ferroptosis and immunotherapy cascade loop. This strategy provides a promising approach to significantly …

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Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches

The readout circuit based on inkjet-printed deep-subthreshold operated thin film transistors (TFTs) based on amorphous indium-gallium-zinc oxide (a-IGZO) successfully digitalizes analog sensor data and provides easy-to-detect visual identification of the sensor signal at a preset threshold crossover using high-current oxide TFTs. Notably, the complete smart sensor patch is shown to operate at a low voltage …

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High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption

Matrix-free solid-state RTP with an average lifetime of 0.50 s is realized in the carbon dots (CDs) synthesized by the one-pot hydrothermal process of powder made of feather wastes. The room-temperature phosphorescence lifetime is further prolonged to 1.97 s by employing polyvinyl alcohol (PVA) and phytic acid (PA). Subsequently, a novel CDs/PVA/PA ink is successfully …

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Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing

An intelligent acid responsive ZIF-8 nanoparticle (CCM + TTD@ZIF-8 NPs) is proposed and is used to promote the healing of burns and infected wounds. It can effectively target bacteria and achieve bacterial imaging under blue light irradiation, effectively releasing CCM and TTD in acidic environments, thereby inhibiting the inflammatory microenvironment and promoting wound healing. Abstract: …

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Trilayer scaffolds were fabricated for biomimicking the anatomical structure of the uterine tissue. They could sustainably release estradiol and were able to transform into curved structures to meet the curvature of uterine tissue. They therefore have a high potential for uterine regeneration. Abstract: Scaffold-based tissue engineering provides an efficient approach for repairing uterine tissue defects …

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Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration

This study aims to understand ATP synthase inhibitory factor 1’s (ATPIF1’s) role in peripheral nerve regeneration (PNR) using a murine model of sciatic nerve crush injury. Histological exams and behavior assessments revealed ATPIF1 absence hindered nerve tissue reconstruction, delaying sensory and functional recovery. RNA-sequencing showed reduced immune responses in ATPIF1 knockout mice, particularly CCR2/CCL2 signaling-mediated …

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Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform

The current monitoring technologies for biological loads in sewage exhibit drawbacks, including low detection efficiency and insufficient accuracy. The authors’ research team has developed an innovative approach that harnesses the power of the CRISPR/Cas12a system within an automated robot-driven photoelectrochemical biosensing platform. This platform allows early detection and tracking of infectious disease outbreaks, providing timely …

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Motorizing the buckled blister for rotary actuation

We explore the rotation of a buckled blister constrained inside an outer ring. The rotation of buckled blister iss actuated via a localized change of curvature, and lower energy-supply is required to initiate the snap-through of buckling compared to conventional bistable mechanism. We experimentally demonstrate the controllability in rotational speed and output torque for a bimetallic …

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Facile construction of dual-response super-resolution probes for tracking organelles dynamics

CPC probe with dual response to LDs polarity and mitochondrial ONOO− developed using a toolkit, which indicates an increase in homogeneity of lipid droplets and fibrous-like mitochondria during ferroptosis that inhibits LDs–mitochondrial interactions. Abstract: Super-resolution imaging techniques, such as structured illumination microscopy (SIM), have enabled researchers to obtain nanoscale organelle-level outputs in living systems, but …

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A self-assembled, genetically engineered, irradiated tumor cell debris vaccine

Sun et al. report on a personized cancer vaccine generated by irradiating GM-CSF overexpressed tumor cells (providing antigens and stimulation signal for APCs), covalent conjugation with hyaluronic acid (improving the persistence of antigen stimulation). The engineered vaccine activated antitumor immunity responses and prevented tumor growth in mice with a single immunization. Abstract: Vaccine-based therapeutics for …

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