Research Article

Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins

Bundled single-walled carbon nanotubes, as artificial neurotrophins, mediate dimerization and phosphorylation of tropomyosin-related kinase B, and stimulate downstream signaling pathways for neuronal survival and differentiation. These therapeutic effects alleviate EtOH-induced neurodegeneration in a rat model. Abstract: The distinguished properties of nanomaterials promote us to explore whether their intrinsic activities would be beneficial to disease treatment. …

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Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy

The therapeutic modality of “chemotherapy-augmented sequential chemoreactive therapy” based on the designed mitochondria-specific nanocatalyst composed of cisplatin prodrug and gallic acid-ferrous (GA-Fe(II)) nanocomposites achieves distinct catalytic cancer-therapeutic performance. The bioactive cisplatin elevates the endogenous H2O2 level through the cascaded reactions, and the GA-Fe(II) nanocomposites with sustainable Fenton catalytic activity subsequently catalyzes H2O2 into hydroxyl radicals …

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Membrane-destabilizing ionizable lipid empowered imaging-guided siRNA delivery and cancer treatment

Development of novel ionizable lipid and realization of real-time payload visualization are of great importance for siRNA delivery and clinical translation. Herein, we fabricated multifunctional ionizable iLNPs based on a newly prepared lipid for targeted delivery of siRNA and MRI contrast agent, which achieved good siRNA transportation, well imaging effect and excellent therapeutic outcome in …

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Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer

A novel supramolecular dendrimeric nanosystem carrying the anticancer drug doxorubicin was developed in this study. We demonstrated this nanosystem markedly overcoming the heterogeneity of drug response and resistance of primary cultured tumor cells derived from 35 PDAC patients. This simple and convenient dendrimer nanodrug holds great promise as a potential candidate to treat the deadly …

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