Research Article

An acid-cleavable Tf-modified engineering exosome-based brain-targeting delivery system (ACTE) was proposed using metabolic glycoengineering and bioorthogonal click chemistry, enabling co-delivery of siTGF-β and DOX for GBM treatment. ACTE was featured by higher BBB transcytosis efficiency and hierarchical targeting delivery to GBM cells. Ds@ACTE effectively reprogrammed the immunosuppressive GBM microenvironment, reducing chemoresistance and enhancing anti-GBM immune …

Engineered brain-targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma Read More »

A mussel-inspired self-assembly strategy is proposed to fabricate silver aerogels based on ultrasmall silver nanoclusters through a dopamine-assisted gelation process. The fabricated silver aerogels possess excellent catalytic and antibacterial properties owing to the synergistic effect of silver nanoclusters and polydopamine, which holds promising potential as novel multifunctional materials for application in environmental and healthcare fields. …

Mussel-inspired self-assembly of silver nanoclusters into multifunctional silver aerogels for enhanced catalytic and bactericidal applications Read More »

High expression of cellular self-activated immunosuppressive molecules and extensive infiltration of suppressive immune cells in the tumor microenvironment are the main factors leading to the resistance of glioma to immunotherapy. This study constructed engineering MSCs expressing IL-12 and nCD47-SLAMF7 (anti-CD47 nanobody combined with the extracellular domain of SLAMF7). Intracranial injection of these two kinds of …

Bioengineer mesenchymal stem cell for treatment of glioma by IL-12 mediated microenvironment reprogramming and nCD47-SLAMF7 mediated phagocytosis regulation of macrophages Read More »

BTO NPs-mediated piezoelectric stimulation effectively induced macrophage M2 polarization and metabolic reprogramming, represented by enhanced TCA cycle and one-carbon folate cycle. After that, anti-inflammatory and pro-differentiation M2 promoted osteogenic differentiation of bone marrow mesenchymal stem cells. The osteo-friendly immune microenvironment formed by piezoelectric stimulation effectively promoted the regeneration of alveolar bone defects. Abstract: Immunomodulation has …

Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages Read More »

Microporous ZIF-67 is synthesized in situ on the 3D interconnected network of bamboo cellulose fibers to produce a multiscale porous filter with a comprehensive pore size distribution. The porous filter has an excellent filtration effect on the particles particulate matter (PM, including PM10, PM2.5 and PM0.3) and harmful gas molecules in the air. Abstract: Air …

Bio-inspired hierarchical bamboo-based air filters for efficient removal of particulate matter and toxic gases Read More »

Herein, a photothermal nanoplatform based on ferric ions (Fe3+), naturally-derived polyphenol gallic acid (GA), model antigen ovalbumin (OVA), and l-buthionine sulfoximine (BSO) was constructed, which can supply with GPX4 inhibitors to eliminate colorectal cancer (CRC) by trapping the tumor cells in the ferroptosis and immunotherapy cascade loop. This strategy provides a promising approach to significantly …

Cascade loop of ferroptosis induction and immunotherapy based on metal-phenolic networks for combined therapy of colorectal cancer Read More »

The readout circuit based on inkjet-printed deep-subthreshold operated thin film transistors (TFTs) based on amorphous indium-gallium-zinc oxide (a-IGZO) successfully digitalizes analog sensor data and provides easy-to-detect visual identification of the sensor signal at a preset threshold crossover using high-current oxide TFTs. Notably, the complete smart sensor patch is shown to operate at a low voltage …

Oxide semiconductor based deep-subthreshold operated read-out electronics for all-printed smart sensor patches Read More »

Matrix-free solid-state RTP with an average lifetime of 0.50 s is realized in the carbon dots (CDs) synthesized by the one-pot hydrothermal process of powder made of feather wastes. The room-temperature phosphorescence lifetime is further prolonged to 1.97 s by employing polyvinyl alcohol (PVA) and phytic acid (PA). Subsequently, a novel CDs/PVA/PA ink is successfully …

High-yield upcycling of feather wastes into solid-state ultra-long phosphorescence carbon dots for advanced anticounterfeiting and information encryption Read More »

An intelligent acid responsive ZIF-8 nanoparticle (CCM + TTD@ZIF-8 NPs) is proposed and is used to promote the healing of burns and infected wounds. It can effectively target bacteria and achieve bacterial imaging under blue light irradiation, effectively releasing CCM and TTD in acidic environments, thereby inhibiting the inflammatory microenvironment and promoting wound healing. Abstract: …

Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging-guided photodynamic therapy of drug-resistant superbug infections and burn wound healing Read More »

Trilayer scaffolds were fabricated for biomimicking the anatomical structure of the uterine tissue. They could sustainably release estradiol and were able to transform into curved structures to meet the curvature of uterine tissue. They therefore have a high potential for uterine regeneration. Abstract: Scaffold-based tissue engineering provides an efficient approach for repairing uterine tissue defects …

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration Read More »