Research Article

SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment

Examining the phenotypes of KRAS mutant and wild-type colorectal cancer cells during anti-EGFR treatment may provide significant insights into drug resistance. Herein, we applied surface-enhanced Raman spectroscopy (SERS) assay to detect four cell surface proteins on KRAS mutant and wild-type cells over a 24-day treatment, where SERS assay achieved multiplexed characterization of cell surface markers …

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Brain co-delivery of first-line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy

We developed temozolomide and epigenetic bromodomain inhibitor co-encapsulated biomimetic nanomedicine (ABNM@TMZ/OTX) achieved multidimensional enhanced glioblastoma synergistic chemoimmunotherapy in both primary and recurrent orthotopic mice models with significant extended survival rate and little side effects. Abstract: Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid development of resistance to mono …

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Exceptional point protected robust on-chip optical logic gates

Non-Hermitian physical principles are introduced into the design of on-chip photonic devices toward high robustness. As a proof-of-concept, an exclusive-or gate on silicon-on-insulator platform is designed by employing the exceptional point encirclement physics. The device performance is extremely robust to structural parameter disturbances, owing to the protection of the photon phase by the topological structure around …

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Drug-grafted DNA as a novel chemogene for targeted combinatorial cancer therapy

A new type of targeted chemogene is constructed through site-specific grafting camptothecins onto a phosphor othioate DNA containing antisense and aptamer segments. With simple and precise structure, the targeted chemogene shows hallmark properties in both in vitro and in vivo evaluations, including active targeting capability, vigorous gene regulation pitency, and prominent antiumor effect, providing new …

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Interplaying coordination and ligand effects to break or make adsorption-energy scaling relations

Currently, it is widely accepted that adsorption-energy scaling relations exist or not depending on the similarity of the adsorbates. Here, we show that CO and OH scale linearly or not on Pt alloys depending on the coordination of the adsorption sites. Hence, ligand and geometric effects can be used to modulate scaling relations, thereby opening …

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Highly branched amylopectin binder for sulfur cathodes with enhanced performance and longevity

Inspired by the extraordinarily resilient and strong binding force of the Great Wall binder, that is, the sticky rice mortar, we extracted highly branched amylopectin, the effective ingredient, as a low-cost, nontoxic, and environmentally benign aqueous binder for high performance and long life sulfur cathode. Abstract: The sulfur cathode of lithium-sulfur (Li-S) batteries suffers from …

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Molecular dynamics simulation‐guided toehold mediated strand displacement probe for single‐nucleotide variants detection

This work provides mechanistic insights into toehold-mediated strand displacement process at the single-nucleotide level through molecular dynamics simulation. Mismatches at the border of the toehold and branch migration domain yield the lowest reaction rate. Based on the simulation results, single nucleotide variants of disease-related genes were detected with high specificity. Abstract: Single nucleotide variant (SNV) …

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Electrochemically induced surface reconstruction of Ni‐Co oxide nanosheet arrays for hybrid supercapacitors

NiCoO nanosheet array (NSA) was converted into hierarchical nanoarrays (ac-NiCoO NSA) through a unique electrochemical activation method. The hierarchical nanostructure, rich oxygen vacancies, antisite defects, and high surface area of ac-NiCoO NSA led to significant electrochemical performance enhancement for supercapacitors. Abstract: Transition metal oxides (TMOs) are promising materials for supercapacitors (SCs) because of their high …

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Rationally designed modular drug delivery platform based on intracellular peptide self-assembly

A general modulated drug-delivery system based on modulated design has realized effective drug delivery. According to the experimental results and theoretical calculations, the general regulations of molecule design are obtained. The regular prediction and rational molecular design will benefit the further construction and optimization of universal drug delivery platform. Abstract: Modulated molecular design-based intracellular self-assembly …

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