Research Article

This study aims to understand ATP synthase inhibitory factor 1’s (ATPIF1’s) role in peripheral nerve regeneration (PNR) using a murine model of sciatic nerve crush injury. Histological exams and behavior assessments revealed ATPIF1 absence hindered nerve tissue reconstruction, delaying sensory and functional recovery. RNA-sequencing showed reduced immune responses in ATPIF1 knockout mice, particularly CCR2/CCL2 signaling-mediated …

Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration Read More »

The current monitoring technologies for biological loads in sewage exhibit drawbacks, including low detection efficiency and insufficient accuracy. The authors’ research team has developed an innovative approach that harnesses the power of the CRISPR/Cas12a system within an automated robot-driven photoelectrochemical biosensing platform. This platform allows early detection and tracking of infectious disease outbreaks, providing timely …

Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform Read More »

We explore the rotation of a buckled blister constrained inside an outer ring. The rotation of buckled blister iss actuated via a localized change of curvature, and lower energy-supply is required to initiate the snap-through of buckling compared to conventional bistable mechanism. We experimentally demonstrate the controllability in rotational speed and output torque for a bimetallic …

Motorizing the buckled blister for rotary actuation Read More »

CPC probe with dual response to LDs polarity and mitochondrial ONOO− developed using a toolkit, which indicates an increase in homogeneity of lipid droplets and fibrous-like mitochondria during ferroptosis that inhibits LDs–mitochondrial interactions. Abstract: Super-resolution imaging techniques, such as structured illumination microscopy (SIM), have enabled researchers to obtain nanoscale organelle-level outputs in living systems, but …

Facile construction of dual-response super-resolution probes for tracking organelles dynamics Read More »

Sun et al. report on a personized cancer vaccine generated by irradiating GM-CSF overexpressed tumor cells (providing antigens and stimulation signal for APCs), covalent conjugation with hyaluronic acid (improving the persistence of antigen stimulation). The engineered vaccine activated antitumor immunity responses and prevented tumor growth in mice with a single immunization. Abstract: Vaccine-based therapeutics for …

A self-assembled, genetically engineered, irradiated tumor cell debris vaccine Read More »

The interface of nanocomposite cathode plays a critical role in the performance of proton-conducting solid oxide fuel cells (H-SOFCs), which has been demonstrated by atomic level studies with the first-principles calculations, nanoscale studies by using the pulsed laser deposition method and the prototype fuel cell studies. The resultant BaZr0.4Co0.6O3 cathode leads to a record-breaking power …

Unveiling the importance of the interface in nanocomposite cathodes for proton-conducting solid oxide fuel cells Read More »

To overcome the pharmacological limitations of artemisinin in cancer therapy, the novel pH-responsive artesunate (ARS)-4-hydroxybenzoyl hydrazide (HBZ)-5-amino levulinic acid (ALA) nanoparticles (AHA NPs) with self-supplied capacity of reactive oxygen species (ROS) were reported to realize excellent chemotherapy and chemodynamic therapy (CDT). Abstract: Prodrug-based self-assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant …

Endoperoxide-enhanced self-assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy Read More »

Using pig cornea as a target, aptamers were selected using the tissue-SELEX method. By attaching the aptamers to liposomes loaded with cyclosporin A, improved treatment of dry eye disease was achieved in vitro and in vivo. Abstract: Cornea is the major barrier to drug delivery to the eye, which results in low bioavailability and poor …

Cornea-SELEX for aptamers targeting the surface of eyes and liposomal drug delivery Read More »

An oxygen-carrying semiconducting polymer nanoprodrug is reported to combine amplified sonodynamic therapy with pyroptosis for deep tumor treatment. The nanoprodrug delivers oxygen to relieve tumor hypoxia microenvironment and thus mediate prodrug activation for pyroptosis. This nanoprodrug-based treatment greatly inhibits the growth of 2-cm chicken breast tissue-covered deep tumors and suppresses tumor metastasis. Abstract: Sonodynamic therapy …

Oxygen-carrying semiconducting polymer nanoprodrugs induce sono-pyroptosis for deep-tissue tumor treatment Read More »

Single cell sequencing revealed AAG, an energy regulatory protein targeting to glycogen, was highly expressed in jellyfish stings-induced CF patients. We postulated AAG could increase glycogen metabolism, protecting against jellyfish stings-induced CF. Intriguingly, AAG improved cardiac function and metabolic adaptation by glycogen-driven ATP production, shifting mitochondrial / glycolytic ATP production towards glycolysis. Sorted by single-cell …

Jellyfish stings-induced cardiac failure was ameliorated through AAG-mediated glycogen-driven ATP production Read More »