Inspired by the extraordinarily resilient and strong binding force of the Great Wall binder, that is, the sticky rice mortar, we extracted highly branched amylopectin, the effective ingredient, as a low-cost, nontoxic, and environmentally benign aqueous binder for high performance and long life sulfur cathode. Abstract: The sulfur cathode of lithium-sulfur (Li-S) batteries suffers from …
This work provides mechanistic insights into toehold-mediated strand displacement process at the single-nucleotide level through molecular dynamics simulation. Mismatches at the border of the toehold and branch migration domain yield the lowest reaction rate. Based on the simulation results, single nucleotide variants of disease-related genes were detected with high specificity. Abstract: Single nucleotide variant (SNV) …
NiCoO nanosheet array (NSA) was converted into hierarchical nanoarrays (ac-NiCoO NSA) through a unique electrochemical activation method. The hierarchical nanostructure, rich oxygen vacancies, antisite defects, and high surface area of ac-NiCoO NSA led to significant electrochemical performance enhancement for supercapacitors. Abstract: Transition metal oxides (TMOs) are promising materials for supercapacitors (SCs) because of their high …
A general modulated drug-delivery system based on modulated design has realized effective drug delivery. According to the experimental results and theoretical calculations, the general regulations of molecule design are obtained. The regular prediction and rational molecular design will benefit the further construction and optimization of universal drug delivery platform. Abstract: Modulated molecular design-based intracellular self-assembly …
The cubic manganese carbonate nanoparticles (MnCO3 NPs) are prepared by a simple synthesis method for enhanced sonodynamic therapy. It is proved that the high sonodynamic performance of MnCO3 NPs is related to its band gap. …
Bundled single-walled carbon nanotubes, as artificial neurotrophins, mediate dimerization and phosphorylation of tropomyosin-related kinase B, and stimulate downstream signaling pathways for neuronal survival and differentiation. These therapeutic effects alleviate EtOH-induced neurodegeneration in a rat model. Abstract: The distinguished properties of nanomaterials promote us to explore whether their intrinsic activities would be beneficial to disease treatment. …
The therapeutic modality of “chemotherapy-augmented sequential chemoreactive therapy” based on the designed mitochondria-specific nanocatalyst composed of cisplatin prodrug and gallic acid-ferrous (GA-Fe(II)) nanocomposites achieves distinct catalytic cancer-therapeutic performance. The bioactive cisplatin elevates the endogenous H2O2 level through the cascaded reactions, and the GA-Fe(II) nanocomposites with sustainable Fenton catalytic activity subsequently catalyzes H2O2 into hydroxyl radicals …
Development of novel ionizable lipid and realization of real-time payload visualization are of great importance for siRNA delivery and clinical translation. Herein, we fabricated multifunctional ionizable iLNPs based on a newly prepared lipid for targeted delivery of siRNA and MRI contrast agent, which achieved good siRNA transportation, well imaging effect and excellent therapeutic outcome in …
A novel supramolecular dendrimeric nanosystem carrying the anticancer drug doxorubicin was developed in this study. We demonstrated this nanosystem markedly overcoming the heterogeneity of drug response and resistance of primary cultured tumor cells derived from 35 PDAC patients. This simple and convenient dendrimer nanodrug holds great promise as a potential candidate to treat the deadly …
