Research Article

Hippocampal Cntnap4 deficiency was associated with cognitive impairment via inducing pro-inflammatory response in females. A biomimetic microglial nanoparticle system (MNPs@PLX) was established for precise microglial delivery of FDA-approved PLX3397 to attenuate cognitive decline, dysfunctional synaptic plasticity, and pro-inflammatory response in female heterozygous Cntnap4 knockout mice. This study indicates that microglial supplementation of PLX3397 may serve as an intervention for …

Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency Read More »

Great progress has been made in ingenious bone tissue engineering for osteonecrosis of the femoral head (ONFH) treatment in the last decades. In this review, we comprehensively summarize the state-of-the-art progress made in bone tissue engineering for ONFH treatment. We also propose insights on the current challenges of these advances in the clinic and the …

Spatiotemporal single-cell transcriptomic profiling reveals inflammatory cell states in a mouse model of diffuse alveolar damage Read More »

Oxidative stress from reactive oxygen species (ROS) is a reperfusion injury factor that can lead to cell damage and death. Ultrasmall Fe-GA CPNs were synthesized to exert a protective role in ischemic brain neurons via removal of ROS, rescuing of glucose metabolism, and suppressing apoptosis through the upregulation of protein kinase B (Akt), antioxidant nuclear …

Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging-guided ischemia stroke therapy Read More »

A facile electric shock method is used to synthesize an efficient, stable, and inexpensive NiCoCuMoW bifunctional alloy electrocatalyst for both hydrogen oxidation reaction (HOR) and hydrogen evolution reaction (HER). Combined experiments and theory calculations reveal that the multi-component synergy of different elements and plentiful active sites render the NiCoCuMoW superior HOR/HER performance, rivaling the Pt/C …

Electroshock synthesis of a bifunctional nonprecious multi-element alloy for alkaline hydrogen oxidation and evolution Read More »

This work describes the construction of bullet-shaped carbon hollow particles with controllable shell thicknesses by heterogeneous interface growth on hard template. As a near infrared light-propelled nanomotor, it shows higher diffusion coefficient and faster velocity by self-thermophoresis for the enhanced dye removal. Abstract: Materials with asymmetric nanostructures have attracted tremendous research attention due to their …

NIR light-propelled bullet-shaped carbon hollow nanomotors with controllable shell thickness for the enhanced dye removal Read More »

This paper demonstrates a novel active-ion-gated strategy to active the room temperature (RT) gas sensing performance of ZnO NWs by self-powered triboelectric plasma system in ambient environment. The activated ZnO NWs shows considerable sensitivity, excellent selectivity, and rapid response to acetone gas at RT with maximum power consumption only 4.5 mW. Abstract: Reducing the high operation …

Active-ion-gated room temperature acetone gas sensing of ZnO nanowires array Read More »

A SOD-inspired copper single-atom nanozyme (Cu-SAzyme) was designed and synthesized by a two-step scaffold-adsorption method. The Cu-SAzyme exhibits high catalytic activity to scavenge superoxide anion, the initiator of ROS, and thus effectively prevents the disease progression in septic animals. Abstract: Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection-caused …

Bioinspired copper single-atom nanozyme as a superoxide dismutase-like antioxidant for sepsis treatment Read More »

We herein developed a nucleus-specific RNAi nanoplatform for targeted regulation of nuclear lncRNA function and effective cancer therapy. This new RNAi nanoplatform could respond to the endosomal pH to expose NTPA/siRNA complexes for the nucleus-specific siRNA delivery, leading to a significant inhibition of nuclear lncNEAT2 expression and tumor growth of liver cancer. Abstract: In the …

Nucleus-specific RNAi nanoplatform for targeted regulation of nuclear lncRNA function and effective cancer therapy Read More »

The CH4 conversion is of great environmental and industrial significance to solve the greenhouse effect. N2 as an optimal activation agent to develop a Pd nanocluster exsolved Ce-incorporated perovskite ferrite catalyst toward lean methane oxidation. The isolated Ce locating at the A-site of perovskite framework facilitates the thermodynamic and kinetics of the Pd exsolution process, lowering the …

Atomic cerium modulated palladium nanoclusters exsolved ferrite catalysts for lean methane conversion Read More »

Environment-friendly InP core/shell quantum dots (QDs) with quantum yield of ∼100% are prepared by aminophosphate precursors. The limit of detection of alpha-fetoprotein for in vitro diagnostics, specific labeling of liver cancer cells, and in vivo tumor-targeted imaging of live mice are comparable to that of the state-of-the-art Cd-QDs-based probes. Abstract: InP quantum dots (QDs) are …

Aminophosphate precursors for the synthesis of near-unity emitting InP quantum dots and their application in liver cancer diagnosis Read More »