Review Article

Modulating macrophages for tumor immunotherapy holds great promise to improve anti-tumor efficacy. Inhibition of macrophage recruitment, depleting tumor-associated macrophages (TAMs), repolarizing TAMs, and regulating macrophage-mediated phagocytosis of tumor cells are the four major strategies for manipulating macrophage-mediated tumor immunotherapy. Abstract: Reprogramming the immunosuppressive tumor microenvironment by modulating macrophages holds great promise in tumor immunotherapy. As …

Harnessing anti-tumor and tumor-tropism functions of macrophages via nanotechnology for tumor immunotherapy Read More »

Allosteric regulation controls the activities of natural enzymes and expands the chemical biology toolbox for the research on switchable catalysts. These rationally designed substitutes for unstable natural enzymes have been applied in areas such as biosensors and biomimetic cascade reactions. This review extended the concept of allosterism to artificial scaffolds and introduced a variety of …

Rational design of allosteric switchable catalysts Read More »

This paper reviews the recent progresses of organic fluorescent nanoprobes (OFNPs) with NIR-IIb emission, focusing on their construction strategies, optical properties, and their applications in deep learning in small animal models such as cerebrovascular imaging, tumor imaging, intestinal imaging, and systemic vascular imaging. In addition, the challenges and potential future research based on NIR-IIb fluorescent …

Organic fluorescent nanoprobes with NIR-IIb characteristics for deep learning Read More »

This review mainly focuses on the recent progress of various liquid organic and solid-state K+ electrolytes for potassium-based batteries. First, the key design principles and applications of organic liquid electrolyte in various battery systems are discussed. Then the research status of ionic liquid, gel/polymer, and solid electrolyte are summarized and evaluated. Finally, this review discusses the …

Electrolyte formulation strategies for potassium-based batteries Read More »

The various catalytic activities of the nanoparticles and their applications in diagnosing and treating viral diseases and their advantages. Abstract: Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared with natural enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, the synthesis of …

Exploration of nanozymes in viral diagnosis and therapy Read More »

Engineered cancer cell membranes (ECCMs) including hybrid CCMs and functionalized CCMs have offered increasing possibilities in the field of cancer theranostics. This review summarizes the recent advances in the development of ECCMs for different biomedical applications, in particular for targeted drug delivery, immunity induction, and circulating tumor cell capture and detection. Abstract: For efficient cancer …

Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics Read More »

Tumor-derived extracellular vesicles can carry malignant factors from tumor cells and help hijack macrophages and microbiota in the tumor microenvironment (TME). In turn, the hijacked macrophages and microbiota can respond with tumor-promoting feedback, achieving a reciprocal coexistence in the TME and working together to facilitate tumor progression. Abstract: The tumor microenvironment (TME) is a biological …

Tumor hijacks macrophages and microbiota through extracellular vesicles Read More »

Mimicking the dynamic ligand presentation in extracellular matrix is crucial to advanced biomaterial design. This review summarizes currently developed dynamic biomaterial interfaces with reversible display of ligands through different molecular strategies. The paradigmatic examples for each strategy as well as their applications in cell regulation are highlighted. Abstract: The extracellular matrix (ECM) provides not only …

Recapitulating dynamic ECM ligand presentation at biomaterial interfaces: Molecular strategies and biomedical prospects Read More »

In this review, we compile the latest work of self-powered multifunction e-skin, discussing related energy sources and coupling techniques. In addition, the latest progress of multifunctional self-powered e-skin for applications in physiological health, human–machine interaction (HMI), virtual reality (VR), and artificial intelligence (AI) are also present. Abstract: Electronic skin (e-skin), new generation of flexible wearable …

Recent progress in self-powered multifunctional e-skin for advanced applications Read More »

This review summarized the advantages and challenges of nanotechnology-based mitochondrial-targeted therapy for neurodegenerative diseases (NDs). In this review, relationships between mitochondrial dysfunction and NDs are discussed; the applications of various NPs in treatment and diagnosis of mitochondrial dysfunction related NDs are also introduced. Abstract: Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes …

Mitochondria-targeted nanoparticles in treatment of neurodegenerative diseases Read More »