Review Article

This review covers the design of cell-based delivery systems for cancer immunotherapy, as well as the significant challenges limiting the efficacy of cell-based immunotherapy and summarizes recent advances in overcoming those barriers to improve cancer treatment outcomes. Abstract: Immunotherapy strategies that use cell-based delivery systems have sparked much interest in the treatment of malignancies, owing …

Recent advances in overcoming barriers to cell-based delivery systems for cancer immunotherapy Read More »

This review mainly focuses on the state-of-the-art CRISPR delivery systems and their applications, categorized by three types of cargo formats, that is, Cas: single-guide RNA ribonucleoprotein, Cas mRNA and single-guide RNA, and Cas plasmid expressing CRISPR/Cas systems. Abstract: Emerging clustered regularly interspaced short palindromic repeat/associated protein (CRISPR/Cas) genome editing technology shows great potential in gene …

Carrier strategies boost the application of CRISPR/Cas system in gene therapy Read More »

Chemodynamic therapy (CDT) utilizes endogenous H2O2 in tumor microenvironment to produce cytotoxic hydroxyl radicals through Fenton or Fenton-like reactions. This review outlines the fundamental understanding of Fenton and Fenton-like reactions and their relationship with CDT and highlights recent research advancements in the design of nanosystems to augment Fenton or Fenton-like reactions for enhanced CDT. Perspectives toward …

Strategies for enhancing cancer chemodynamic therapy performance Read More »

G-quadruplexes involve in various biological processes in living cells, and are considered as a promising new target for disease therapeutics, but the detailed mechanism of G4 biofunction remains elusive. This review highlights recent methodological advances about intracellular G-quadruplexes and provides an outlook on the improvement of the bioanalysis and biochemical targeting tools of G-quadruplexes. Abstract: …

Methodological advances of bioanalysis and biochemical targeting of intracellular G-quadruplexes Read More »

Modulating macrophages for tumor immunotherapy holds great promise to improve anti-tumor efficacy. Inhibition of macrophage recruitment, depleting tumor-associated macrophages (TAMs), repolarizing TAMs, and regulating macrophage-mediated phagocytosis of tumor cells are the four major strategies for manipulating macrophage-mediated tumor immunotherapy. Abstract: Reprogramming the immunosuppressive tumor microenvironment by modulating macrophages holds great promise in tumor immunotherapy. As …

Harnessing anti-tumor and tumor-tropism functions of macrophages via nanotechnology for tumor immunotherapy Read More »

Allosteric regulation controls the activities of natural enzymes and expands the chemical biology toolbox for the research on switchable catalysts. These rationally designed substitutes for unstable natural enzymes have been applied in areas such as biosensors and biomimetic cascade reactions. This review extended the concept of allosterism to artificial scaffolds and introduced a variety of …

Rational design of allosteric switchable catalysts Read More »

This paper reviews the recent progresses of organic fluorescent nanoprobes (OFNPs) with NIR-IIb emission, focusing on their construction strategies, optical properties, and their applications in deep learning in small animal models such as cerebrovascular imaging, tumor imaging, intestinal imaging, and systemic vascular imaging. In addition, the challenges and potential future research based on NIR-IIb fluorescent …

Organic fluorescent nanoprobes with NIR-IIb characteristics for deep learning Read More »

This review mainly focuses on the recent progress of various liquid organic and solid-state K+ electrolytes for potassium-based batteries. First, the key design principles and applications of organic liquid electrolyte in various battery systems are discussed. Then the research status of ionic liquid, gel/polymer, and solid electrolyte are summarized and evaluated. Finally, this review discusses the …

Electrolyte formulation strategies for potassium-based batteries Read More »

The various catalytic activities of the nanoparticles and their applications in diagnosing and treating viral diseases and their advantages. Abstract: Nanozymes are nanomaterials with similar catalytic activities to natural enzymes. Compared with natural enzymes, they have numerous advantages, including higher physiochemical stability, versatility, and suitability for mass production. In the past decade, the synthesis of …

Exploration of nanozymes in viral diagnosis and therapy Read More »

Engineered cancer cell membranes (ECCMs) including hybrid CCMs and functionalized CCMs have offered increasing possibilities in the field of cancer theranostics. This review summarizes the recent advances in the development of ECCMs for different biomedical applications, in particular for targeted drug delivery, immunity induction, and circulating tumor cell capture and detection. Abstract: For efficient cancer …

Engineered cancer cell membranes: An emerging agent for efficient cancer theranostics Read More »