This study describes a novel nanobody that could induce the trimer dimers conformation of the Spike protein to neutralize the SARS-CoV-2 infection. This nanobody exhibits a broad neutralizing spectrum against various SARS-CoV-2 variants and has the potential to be administered through inhalation. Abstract: The ongoing mutations of the SARS-CoV-2 pose serious challenges to the efficacy …
Previously, the effect of soil mineral N deficiency on nodule nitrogen fixation capacity (NFC) is unclear. In this study, we found that N deficiency would enhance sucrose allocation to nodules and PEP allocation to bacteroid to promote nodule NFC. Our findings provide new insights into the design of leguminous crops with improved adaptation to fluctuating …
We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial organization of lysosomes against mitochondria during mitophagy by using super resolution microscopy. Abstract: Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome …
This report describes the 3D fabrication of the microneedles with the open groove channels for skin interstitial fluid extraction through capillary force. Biomarkers in the extracted liquid (e.g. glucose) can be analyzed in situ by the commercial test strips attached to the back of microneedles. Abstract: Microneedles (MNs) offer a simple and minimally invasive way …
3D-printed microneedles with open groove channels for liquid extraction Read More »
Nature relies on the exploitation of sunlight and hydrogen ions to enable uphill organic reactions, namely photosynthesis. Herein, a biomimetic organic semiconductor composed of abundant elements (C, N, and K) uses this strategy to accumulate light energy and store hydrogen ions as powerful tool for synthetic organic chemistry in the flask. Abstract: A combination of …
Multisite PCET with photocharged carbon nitride in dark Read More »
Superplastic metal–organic framework (MOF) assembled macroscopic architecture is reported for the first time, which can fully and rapidly recover to its initial states…
