Short Communication

Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe

We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial organization of lysosomes against mitochondria during mitophagy by using super resolution microscopy. Abstract: Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome …

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3D-printed microneedles with open groove channels for liquid extraction

This report describes the 3D fabrication of the microneedles with the open groove channels for skin interstitial fluid extraction through capillary force. Biomarkers in the extracted liquid (e.g. glucose) can be analyzed in situ by the commercial test strips attached to the back of microneedles. Abstract: Microneedles (MNs) offer a simple and minimally invasive way …

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Multisite PCET with photocharged carbon nitride in dark

Nature relies on the exploitation of sunlight and hydrogen ions to enable uphill organic reactions, namely photosynthesis. Herein, a biomimetic organic semiconductor composed of abundant elements (C, N, and K) uses this strategy to accumulate light energy and store hydrogen ions as powerful tool for synthetic organic chemistry in the flask. Abstract: A combination of …

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