Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial organization of lysosomes against mitochondria during mitophagy by using super resolution microscopy. Abstract: Lysosomes are multifunctional organelles involved in macromolecule degradation, nutrient sensing, and autophagy. Live imaging has revealed lysosome …