Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core-Shell Manganese Phosphate/siPD-L1 Modulator
To enhance the comprehensive treatment effect of triple-negative breast cancer, a pH-responsive core-shell manganese phosphate nano-regulator was prepared to reprogram the tumor microenvironment bi-directionally. (1)
Dual-Responsive Multi-Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury
Targeting mitochondrial dysfunction presents a potential therapeutic approach for treating spinal cord injury. We have successfully designed and synthesized a functional Se@NADH nanodrug system. This
Efficient Ternary Organic Photovoltaic Films for Fast Exciton Separation to Generate Free Radicals for Wastewater Treatment
For the first time, application results are reported at the intersection of organic photovoltaics and photocatalysis: An insertion strategy based on morphology modulation is proposed
Elastic Nanoparticle-Reinforced, Conductive Structural Color Hydrogel With Super Stretchability, Self-Adhesion, Self-Healing as Electrical/Optical Dual-Responsive Visual Electronic Skins
A conductive structural color hydrogel with highly charged elastic nanoparticles was developed by implementing a simple one-step assembly and photopolymerization strategy that can achieve excellent
Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules
This project develops a biomimetic stent coating with a double presentation of therapeutic biomacromolecule VEGF and therapeutic gas NO, which spatiotemporally promotes vessel repair including
Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation
Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma-associated oncogene-1 (Gli1) in the
Short Communication
A novel nanobody broadly neutralizes SARS-CoV-2 via induction of spike trimer dimers conformation
This study describes a novel nanobody that could induce the trimer dimers conformation of the Spike protein to neutralize the SARS-CoV-2 infection. This nanobody exhibits
Nitrogen deficiency modulates carbon allocation to promote nodule nitrogen fixation capacity in soybean
Previously, the effect of soil mineral N deficiency on nodule nitrogen fixation capacity (NFC) is unclear. In this study, we found that N deficiency would
Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial
3D-printed microneedles with open groove channels for liquid extraction
This report describes the 3D fabrication of the microneedles with the open groove channels for skin interstitial fluid extraction through capillary force. Biomarkers in the
Multisite PCET with photocharged carbon nitride in dark
Nature relies on the exploitation of sunlight and hydrogen ions to enable uphill organic reactions, namely photosynthesis. Herein, a biomimetic organic semiconductor composed of abundant
Biomimetic assembly to superplastic metal–organic framework aerogels for hydrogen evolution from seawater electrolysis
Superplastic metal–organic framework (MOF) assembled macroscopic architecture is reported for the first time, which can fully and rapidly recover to its initial states…