SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment
Examining the phenotypes of KRAS mutant and wild-type colorectal cancer cells during anti-EGFR treatment may provide significant insights into drug resistance. Herein, we applied surface-enhanced
Brain co-delivery of first-line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy
We developed temozolomide and epigenetic bromodomain inhibitor co-encapsulated biomimetic nanomedicine (ABNM@TMZ/OTX) achieved multidimensional enhanced glioblastoma synergistic chemoimmunotherapy in both primary and recurrent orthotopic mice models
Exceptional point protected robust on-chip optical logic gates
Non-Hermitian physical principles are introduced into the design of on-chip photonic devices toward high robustness. As a proof-of-concept, an exclusive-or gate on silicon-on-insulator platform is designed
Drug-grafted DNA as a novel chemogene for targeted combinatorial cancer therapy
A new type of targeted chemogene is constructed through site-specific grafting camptothecins onto a phosphor othioate DNA containing antisense and aptamer segments. With simple and
Interplaying coordination and ligand effects to break or make adsorption-energy scaling relations
Currently, it is widely accepted that adsorption-energy scaling relations exist or not depending on the similarity of the adsorbates. Here, we show that CO and
Highly branched amylopectin binder for sulfur cathodes with enhanced performance and longevity
Inspired by the extraordinarily resilient and strong binding force of the Great Wall binder, that is, the sticky rice mortar, we extracted highly branched amylopectin,
Short Communication
Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial
3D-printed microneedles with open groove channels for liquid extraction
This report describes the 3D fabrication of the microneedles with the open groove channels for skin interstitial fluid extraction through capillary force. Biomarkers in the
Multisite PCET with photocharged carbon nitride in dark
Nature relies on the exploitation of sunlight and hydrogen ions to enable uphill organic reactions, namely photosynthesis. Herein, a biomimetic organic semiconductor composed of abundant
Biomimetic assembly to superplastic metal–organic framework aerogels for hydrogen evolution from seawater electrolysis
Superplastic metal–organic framework (MOF) assembled macroscopic architecture is reported for the first time, which can fully and rapidly recover to its initial states…