Rationally designed modular drug delivery platform based on intracellular peptide self-assembly
A general modulated drug-delivery system based on modulated design has realized effective drug delivery. According to the experimental results and theoretical calculations, the general regulations
Manganese carbonate nanoparticles-mediated mitochondrial dysfunction for enhanced sonodynamic therapy
The cubic manganese carbonate nanoparticles (MnCO3 NPs) are prepared by a simple synthesis method for enhanced sonodynamic therapy. It is proved that the high sonodynamic performance of MnCO3 NPs is related to its band gap. …
Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins
Bundled single-walled carbon nanotubes, as artificial neurotrophins, mediate dimerization and phosphorylation of tropomyosin-related kinase B, and stimulate downstream signaling pathways for neuronal survival and differentiation.
Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy
The therapeutic modality of “chemotherapy-augmented sequential chemoreactive therapy” based on the designed mitochondria-specific nanocatalyst composed of cisplatin prodrug and gallic acid-ferrous (GA-Fe(II)) nanocomposites achieves distinct
Membrane-destabilizing ionizable lipid empowered imaging-guided siRNA delivery and cancer treatment
Development of novel ionizable lipid and realization of real-time payload visualization are of great importance for siRNA delivery and clinical translation. Herein, we fabricated multifunctional
Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer
A novel supramolecular dendrimeric nanosystem carrying the anticancer drug doxorubicin was developed in this study. We demonstrated this nanosystem markedly overcoming the heterogeneity of drug
Short Communication
Biomimetic assembly to superplastic metal–organic framework aerogels for hydrogen evolution from seawater electrolysis
Superplastic metal–organic framework (MOF) assembled macroscopic architecture is reported for the first time, which can fully and rapidly recover to its initial states…