The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR-related mRNA at the 5′ ss and 3′ ss, generating two
Morphology Engineering of SnS2 Nanostructures to Stimulate PICT Resonance for Ultra-Sensitive SERS Sensors
The developed SnS2 nanostrctures with three morphology of stacked nanosheets, microspheresand microflowers exhibit the excellent SERS enhanced uniformity, generality, stability and ultra-high sensitivity, which are
Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia
We identified a harmful immune cell type, p21+CD86+ microglia, driving post-stroke inflammation and developed a targeted exosome-based therapy (Que@micro-Exo) to eliminate these cells. This innovative treatment
Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts
Multifunctional and reusable PHC wound dressing was designed for accelerating movable wound healing process. With alternated NIR light irradiation, PHC can produce abundant heat and
Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme-Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy
Self-assembled S-Cu(I)-S sites were spatially isolated onto a two-dimensional Ti3C2 surface to produce a structurally well-defined and highly functional single-site copper(I) nanomodulator CuNTD, which can induce
Surface-Anchored Ticagrelor Gelatin Nanoparticles-Platelets System for Enhanced Anti-PD-L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines
Ticagrelor nanoparticles modified platelets could adhere to tumor-associated platelets by specific recruiting ability and responsively release ticagrelor under MMPs stimulation. The released ticagrelor could inhibit
Short Communication
A novel nanobody broadly neutralizes SARS-CoV-2 via induction of spike trimer dimers conformation
This study describes a novel nanobody that could induce the trimer dimers conformation of the Spike protein to neutralize the SARS-CoV-2 infection. This nanobody exhibits
Nitrogen deficiency modulates carbon allocation to promote nodule nitrogen fixation capacity in soybean
Previously, the effect of soil mineral N deficiency on nodule nitrogen fixation capacity (NFC) is unclear. In this study, we found that N deficiency would
Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial
3D-printed microneedles with open groove channels for liquid extraction
This report describes the 3D fabrication of the microneedles with the open groove channels for skin interstitial fluid extraction through capillary force. Biomarkers in the
Multisite PCET with photocharged carbon nitride in dark
Nature relies on the exploitation of sunlight and hydrogen ions to enable uphill organic reactions, namely photosynthesis. Herein, a biomimetic organic semiconductor composed of abundant
Biomimetic assembly to superplastic metal–organic framework aerogels for hydrogen evolution from seawater electrolysis
Superplastic metal–organic framework (MOF) assembled macroscopic architecture is reported for the first time, which can fully and rapidly recover to its initial states…