Burst of hopping trafficking correlated reversible dynamic interactions between lipid droplets and mitochondria under starvation
The reversible interactions between LDs and mitochondria are tracked in real-time using a robust LDs-specific fluorescent probe (LDs-Tags). LDs exhibit active transport and are inclined
Tumor microenvironment-responsive delivery nanosystems reverse immunosuppression for enhanced CO gas/immunotherapy
TME-responsive delivery nanosystems with rough surfaces (M-RMH) are proposed to enhance CO gas/immunotherapy through immune activation and immunosuppression regulation simultaneously. After the combination with aPD-L1-mediated
Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment
Overexpression of the EGFR is found in up to 74% of bladder cancer (BCa) tissue. Two natural products that were found, triptolide (TPL) and hesperidin
Atomically Fe-anchored MOF-on-MOF nanozyme with differential signal amplification for ultrasensitive cathodic electrochemiluminescence immunoassay
An ultrasensitive cathodic electrochemiluminescence immunoassay was developed by designing atomically Fe-anchored MOF-on-MOF nanozymes (CoNi-MOF@PCN-224/Fe) as ECL electrode materials and plasmonic Ag/AuNCs as high-efficient co-reactant quenchers.
Visual genetic typing of glioma using proximity-anchored in situ spectral coding amplification
This research developed a novel multiplexed imaging method of RNA mutations, named proximity-anchored in situ spectral coding amplification (ProxISCA), enabling visual typing of brain gliomas
Dynamic regulation of drug biodistribution by turning tumors into decoys for biomimetic nanoplatform to enhance the chemotherapeutic efficacy of breast cancer with bone metastasis
The schematic diagram of EMM@DJHAD NPs destroys tumor cells via the synergism of DAC and JTC. The former enriches the level of gasdermin E in tumor by
Short Communication
Super-resolution analyzing spatial organization of lysosomes with an organic fluorescent probe
We designed and synthesized an organic small fluorescence probe with a large Stokes shift. With this probe specifically targeting lysosomes, we revealed a distinct spatial
3D-printed microneedles with open groove channels for liquid extraction
This report describes the 3D fabrication of the microneedles with the open groove channels for skin interstitial fluid extraction through capillary force. Biomarkers in the
Multisite PCET with photocharged carbon nitride in dark
Nature relies on the exploitation of sunlight and hydrogen ions to enable uphill organic reactions, namely photosynthesis. Herein, a biomimetic organic semiconductor composed of abundant
Biomimetic assembly to superplastic metal–organic framework aerogels for hydrogen evolution from seawater electrolysis
Superplastic metal–organic framework (MOF) assembled macroscopic architecture is reported for the first time, which can fully and rapidly recover to its initial states…