Receptor-targeting nanomaterials alleviate binge drinking-induced neurodegeneration as artificial neurotrophins
Bundled single-walled carbon nanotubes, as artificial neurotrophins, mediate dimerization and phosphorylation of tropomyosin-related kinase B, and stimulate downstream signaling pathways for neuronal survival and differentiation.
Mitochondria-specific nanocatalysts for chemotherapy-augmented sequential chemoreactive tumor therapy
The therapeutic modality of “chemotherapy-augmented sequential chemoreactive therapy” based on the designed mitochondria-specific nanocatalyst composed of cisplatin prodrug and gallic acid-ferrous (GA-Fe(II)) nanocomposites achieves distinct
Membrane-destabilizing ionizable lipid empowered imaging-guided siRNA delivery and cancer treatment
Development of novel ionizable lipid and realization of real-time payload visualization are of great importance for siRNA delivery and clinical translation. Herein, we fabricated multifunctional
Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer
A novel supramolecular dendrimeric nanosystem carrying the anticancer drug doxorubicin was developed in this study. We demonstrated this nanosystem markedly overcoming the heterogeneity of drug