Research Article

To enhance the comprehensive treatment effect of triple-negative breast cancer, a pH-responsive core-shell manganese phosphate nano-regulator was prepared to reprogram the tumor microenvironment bi-directionally. (1) “Brakes off”: Using siPD-L1 to inhibit PD-L1 expression to restore CD8+ T cell function. 2) “Step on the accelerator”: Based on Mn2+’s effect, promoting CD8+ T cell infiltration and maturation. …

Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a “Brakes Off/ Step on the Accelerator” Core-Shell Manganese Phosphate/siPD-L1 Modulator Read More »

Targeting mitochondrial dysfunction presents a potential therapeutic approach for treating spinal cord injury. We have successfully designed and synthesized a functional Se@NADH nanodrug system. This system offers neuroprotective and neuroregenerative benefits by modulating mitochondrial function and neutralizing reactive oxygen species, thereby reducing oxidative damage and neuronal apoptosis. Abstract: Preserved/rescued mitochondrial functions have a significant effect …

Dual-Responsive Multi-Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury Read More »

For the first time, application results are reported at the intersection of organic photovoltaics and photocatalysis: An insertion strategy based on morphology modulation is proposed to reduce the π–π stacking distance, improve charge transport, and increase device efficiency. Ternary organic photovoltaic films were applied to wastewater treatment, and the removal rate of ionic Sb(III) and …

Efficient Ternary Organic Photovoltaic Films for Fast Exciton Separation to Generate Free Radicals for Wastewater Treatment Read More »

A conductive structural color hydrogel with highly charged elastic nanoparticles was developed by implementing a simple one-step assembly and photopolymerization strategy that can achieve excellent mechanical robustness, self-adhesiveness, self-healing properties, as well as synchronous electronic and visual signal monitoring for interactively visual electronic skins. Abstract: Developing smart hydrogel with excellent physicochemical properties and multiple signal …

Elastic Nanoparticle-Reinforced, Conductive Structural Color Hydrogel With Super Stretchability, Self-Adhesion, Self-Healing as Electrical/Optical Dual-Responsive Visual Electronic Skins Read More »

This project develops a biomimetic stent coating with a double presentation of therapeutic biomacromolecule VEGF and therapeutic gas NO, which spatiotemporally promotes vessel repair including promoting rapid re-endothelialization, effectively preventing thrombosis, suppressing inflammation and restenosis. Abstract: Endothelial injury is a common occurrence following stent implantation, often leading to complications such as restenosis and thrombosis. To …

Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules Read More »

Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma-associated oncogene-1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional activity and regulates the antiapoptotic mediator’s (Bcl2) expression, which induces …

Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation Read More »

Illustration of Pd NP-mediated rescue of HGHF (or advanced glycation end products [AGEs])-induced IVD degeneration by targeting AGEs degradation. Pd NPs promote the ATPase activity of VCP and upregulate autophagosome formation to degrade AGEs. Consequently, Pd NPs alleviate the oxidative and ER stress, protect the structure and function of mitochondria, and eventually facilitate IVDD mitigation. …

Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin-Containing Protein Mediated Autophagy to Attenuate High-Glucose/High-Fat-Induced Intervertebral Disc Degeneration Read More »

For the first time, a simple organic structural unit (2-methylimidazole, 2-MIM) is used to collect a mixture of two metal precursors (CsI and CuI) and successfully synthesize an all-inorganic lead-free yellow light CsCu2I3 powder in water. The stable and efficient CsCu2I3 powder shows promising exciting potential applications in photoluminescence and phototherapy fields. Abstract: Yellow light-emitting …

Direct synthesis of high quantum yield lead-free CsCu2I3 powder in water and its application in yellow LED Read More »

In this study, the authors have developed a library of antigen/adjuvant-free liposomes for testing the adjuvant effects. The anionic liposomes with appropriate surface charges enhance host immunity by regulating the Th1, Th2 and CD8+ T cells in lymphoid organs with good safety. It shows efficient therapy against MC38 colorectal cancer when combined with tumor antigens. …

Antigen/adjuvant-free liposome induces adjuvant effects for enhancing cancer immunotherapy Read More »

In this research, a nanoparticle formulation, Parthenolide/ICG-CaCO3@Lipid (PTL/ICG-CaCO3@Lip), has been engineered to amplify ferroptosis in tumor cells, positioning it as a potent agent for sonodynamic cancer immunotherapy. This nanoparticle significantly augments ROS levels within tumor cells, inducing oxidative stress, and regulating P53 to downregulate SLC7A11 protein expression, thereby inhibiting the glutamate-cystine antiporter system Xc- and …

A pH responsive nanocomposite for combination sonodynamic-immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway Read More »