The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells
Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR-related mRNA at the 5′ ss and 3′ ss, generating two mature mRNA isoforms, which are ultimately translated into CSR-related proteins. These CSR-related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, …
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