Research Article

Bcas2 recruits DHX15 and SRSF7 to form a protein complex for the splicing of CSR-related mRNA at the 5′ ss and 3′ ss, generating two mature mRNA isoforms, which are ultimately translated into CSR-related proteins. These CSR-related proteins bind to DNA associated with antibodies, affecting the DSB repair of the relevant DNA after AID induction, …

The RNA Binding Protein Bcas2 is Required for Antibody Class Switch in Activated-B Cells Read More »

The developed SnS2 nanostrctures with three morphology of stacked nanosheets, microspheresand microflowers exhibit the excellent SERS enhanced uniformity, generality, stability and ultra-high sensitivity, which are expected to provide a class of potential commercial SERS-active materials for the practical application of semiconductor-based SERS technology. Abstract: Recent advances indicate the surface-enhanced Raman scattering (SERS) sensitivity of semiconductors …

Morphology Engineering of SnS2 Nanostructures to Stimulate PICT Resonance for Ultra-Sensitive SERS Sensors Read More »

We identified a harmful immune cell type, p21+CD86+ microglia, driving post-stroke inflammation and developed a targeted exosome-based therapy (Que@micro-Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other central nervous system disorders. Abstract: Stroke remains the leading cause of …

Engineered Exosome-Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia Read More »

Multifunctional and reusable PHC wound dressing was designed for accelerating movable wound healing process. With alternated NIR light irradiation, PHC can produce abundant heat and ROS for bacteria inactivation due to its photothermal and pyroelectric property. With the frequent movement of movable wound, PHC can effectively promote cell migration and proliferation due to its piezoelectric …

Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts Read More »

Self-assembled S-Cu(I)-S sites were spatially isolated onto a two-dimensional Ti3C2 surface to produce a structurally well-defined and highly functional single-site copper(I) nanomodulator CuNTD, which can induce severe immunogenic cell death through multiple regulatory pathways of synergistic cascade photothermal-amplified ROS storms, cuproptosis and ferroptosis for cancer immunotherapy. Abstract: Nanozyme-based immunogenic cell death (ICD) inducers that effectively induce …

Spatial Isolation of Single Copper(I) Sites for Cascade Enzyme-Like Catalysis and Simultaneous Ferroptosis/Cuproptosis Boosted Immunotherapy Read More »

Ticagrelor nanoparticles modified platelets could adhere to tumor-associated platelets by specific recruiting ability and responsively release ticagrelor under MMPs stimulation. The released ticagrelor could inhibit platelets activity, enhancing tumor treatment efficacy. Abstract: The tumor microenvironment is characterized by immunosuppression and compromised intratumoral perfusion, which impairs the effectiveness of immune checkpoint inhibitors and nanomedicines. A significant …

Surface-Anchored Ticagrelor Gelatin Nanoparticles-Platelets System for Enhanced Anti-PD-L1 Therapy Response and Boosted Chemotherapeutic Efficacy of Nanomedicines Read More »

BACE1 interfering RNA, metallothionein and ruthenium complexes ([Ru(bpy)2dppz]2+) were all loaded in prussian blue nanoparticles (PRM-siRNA). PRM-siRNA under near-infrared light irradiation showed good photothermal effect and triggered instantaneous opening of blood-brain barrier for enhanced drug delivery. BACE1 siRNA slowed down Aβ production, and Cu2+ chelation by metallothionein synergistically inhibited Aβ aggregation, and finally improved APP/PS1 mice …

Enhanced Blood-Brain Barrier Penetrability of BACE1 SiRNA-Loaded Prussian Blue Nanocomplexes for Alzheimer’s Disease Synergy Therapy Read More »

This study investigated the role of the βB2-crystallin c.562C>T (p.R188C) mutation in congenital cataract. Clinical pedigree analysis, combined with whole-exome sequencing (WES), identified this pathogenic variant. Bioinformatic analyses predicted destabilization of the mutant protein’s tertiary structure, potentially impairing its function. In vitro experiments demonstrated that the mutant protein formed aggregates under cellular stress, which were …

Cataract-Causing Mutant R188C of βB2 Crystallin With Low Structural Stability is Sensitive to Environmental Stresses and Prone to Aggregates Formation Read More »

Hypoxia and acidic microenvironments are characteristic features of solid tumors, driving tumor growth, drug resistance, and metastasis. To address these issues, we combined hyperbaric oxygen therapy with rational designed hydroxyethyl starch-doxorubicin-copper nanoparticles to modulate the acidic microenvironment of tumors while enhancing the efficacy of chemotherapy and chemodynamic therapy to effectively kill hypoxic solid tumors. Our …

Hyperbaric Oxygen Regulates Tumor pH to Boost Copper-Doped Hydroxyethyl Starch Conjugate Nanoparticles Against Cancer Stem Cells Read More »

In the absence of catalysts and additives, under only ambient temperature and light conditions, organic compounds undergo vibrational relaxation processes after photon excitation, followed by direct C-H cleavage to generate hydrogen radicals and carbon radicals. The substrate scope is broad, ranging from benzylic substrates to alcohols, alkenes, alkanes, benzylic hydrogen-containing polymers, and even gaseous methane. …

Room-Temperature Direct Homolysis of Csp3─H Bond via Catalyst-Free Photoexcitation Read More »