Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging-guided ischemia stroke therapy
Oxidative stress from reactive oxygen species (ROS) is a reperfusion injury factor that can lead to cell damage and death. Ultrasmall Fe-GA CPNs were synthesized to exert a protective role in ischemic brain neurons via removal of ROS, rescuing of glucose metabolism, and suppressing apoptosis through the upregulation of protein kinase B (Akt), antioxidant nuclear …