Research Article

Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress

In this study, Wang et al. explored the potential pathogenesis of chronic social defeat stress (CSDS)-induced depressive-like behaviour in mice using 10× Visium spatial transcriptomics (ST) technique. Many of the depression-related gene changes were identified and more pronounced in the hippocampus (HIP), cortex (Isocortex), and amygdala (AMY) in susceptible (SUS) mice compared to control and resilient …

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Early monitoring-to-warning Internet of Things system for emerging infectious diseases via networking of light-triggered point-of-care testing devices

There is still no epidemic surveillance system, implementing prevention and control measures is slow and inefficient. This study developed a rapid point-of-care (POC) testing device for detecting pathogens. Through multi-device networking, an early monitoring and warning system for major infectious diseases was developed. This study makes a contribution to the urgent need for a system …

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Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor

This study presents a novel surface modification approach aimed at enhancing the biomedical applications of Salmonella. By employing a facile surface engineering technique involving pH-responsive polyserotonin (PST) and self-activated DNAzyme, the immune clearance and non-specific colonization of Salmonella can be effectively mitigated. The PST coating exhibits the ability to disassemble in acidic tumor microenvironments, thereby facilitating the controlled …

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Electrospun PEO/PEG fibers as potential flexible phase change materials for thermal energy regulation

Thermal regulating fabrics are highly applicable in various industries such as bandages, wearable devices, clothing, or facemasks. In this work, PEO is electrospun with PEG as the PCM and plasticizer component, which show great compatibility and produce uniform fibers. Presence of PEG significantly improve the fiber’s mechanical properties, and supercooling for PEG component effectively reduce …

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Models of light absorption enhancement in perovskite solar cells by plasmonic nanoparticles

The experimental literature on plasmonic perovskite solar cells is analyzed in light of this theoretical description. It is estimated that only a small portion of these reports can be associated with light absorption and point out the importance of reporting the perovskite thickness and nanoparticle concentration in order to assess the presence of plasmonic effects …

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Designing advanced S-scheme CdS QDs/La-Bi2WO6 photocatalysts for efficient degradation of RhB

S-scheme CdS QDs/La-Bi2WO6 photocatalysts are successfully designed and synthesized by coupling element doping and constructing. The photocatalytic mechanism of the S-scheme heterojunction was analyzed by the test of photocatalytic performance, crystal characterization and theoretical calculation, which provides an approach to design advanced photocatalysts by coupling element doping and constructing heterostructures. Abstract: Finding effective strategies to design …

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Burst of hopping trafficking correlated reversible dynamic interactions between lipid droplets and mitochondria under starvation

The reversible interactions between LDs and mitochondria are tracked in real-time using a robust LDs-specific fluorescent probe (LDs-Tags). LDs exhibit active transport and are inclined to repeatedly search for a suitable contact site on the mitochondrial membrane under nutrient starvation. Intermittent larger jumps are observed between clustered small steps during this process. Abstract: Dynamic membrane …

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Tumor microenvironment-responsive delivery nanosystems reverse immunosuppression for enhanced CO gas/immunotherapy

TME-responsive delivery nanosystems with rough surfaces (M-RMH) are proposed to enhance CO gas/immunotherapy through immune activation and immunosuppression regulation simultaneously. After the combination with aPD-L1-mediated checkpoint blockade therapy, robust antitumor immune responses are found to inhibit both primary and distant tumors. Abstract: Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis …

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Small-molecule nanoprodrug with high drug loading and EGFR, PI3K/AKT dual-inhibiting properties for bladder cancer treatment

Overexpression of the EGFR is found in up to 74% of bladder cancer (BCa) tissue. Two natural products that were found, triptolide (TPL) and hesperidin (HSP), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles in a water environment, which not only remarkably improved their bioavailability and therapeutic but …

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Atomically Fe-anchored MOF-on-MOF nanozyme with differential signal amplification for ultrasensitive cathodic electrochemiluminescence immunoassay

An ultrasensitive cathodic electrochemiluminescence immunoassay was developed by designing atomically Fe-anchored MOF-on-MOF nanozymes (CoNi-MOF@PCN-224/Fe) as ECL electrode materials and plasmonic Ag/AuNCs as high-efficient co-reactant quenchers. The proposed differential signal amplification strategy endowed the immunoassay with superior detection ability, which provide more possibilities for the ultrasensitive detection of disease markers in clinical diagnosis. Abstract: The successful …

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