In this study, Wang et al. explored the potential pathogenesis of chronic social defeat stress (CSDS)-induced depressive-like behaviour in mice using 10× Visium spatial transcriptomics (ST) technique. Many of the depression-related gene changes were identified and more pronounced in the hippocampus (HIP), cortex (Isocortex), and amygdala (AMY) in susceptible (SUS) mice compared to control and resilient …
There is still no epidemic surveillance system, implementing prevention and control measures is slow and inefficient. This study developed a rapid point-of-care (POC) testing device for detecting pathogens. Through multi-device networking, an early monitoring and warning system for major infectious diseases was developed. This study makes a contribution to the urgent need for a system …
This study presents a novel surface modification approach aimed at enhancing the biomedical applications of Salmonella. By employing a facile surface engineering technique involving pH-responsive polyserotonin (PST) and self-activated DNAzyme, the immune clearance and non-specific colonization of Salmonella can be effectively mitigated. The PST coating exhibits the ability to disassemble in acidic tumor microenvironments, thereby facilitating the controlled …
Thermal regulating fabrics are highly applicable in various industries such as bandages, wearable devices, clothing, or facemasks. In this work, PEO is electrospun with PEG as the PCM and plasticizer component, which show great compatibility and produce uniform fibers. Presence of PEG significantly improve the fiber’s mechanical properties, and supercooling for PEG component effectively reduce …
The experimental literature on plasmonic perovskite solar cells is analyzed in light of this theoretical description. It is estimated that only a small portion of these reports can be associated with light absorption and point out the importance of reporting the perovskite thickness and nanoparticle concentration in order to assess the presence of plasmonic effects …
S-scheme CdS QDs/La-Bi2WO6 photocatalysts are successfully designed and synthesized by coupling element doping and constructing. The photocatalytic mechanism of the S-scheme heterojunction was analyzed by the test of photocatalytic performance, crystal characterization and theoretical calculation, which provides an approach to design advanced photocatalysts by coupling element doping and constructing heterostructures. Abstract: Finding effective strategies to design …
The reversible interactions between LDs and mitochondria are tracked in real-time using a robust LDs-specific fluorescent probe (LDs-Tags). LDs exhibit active transport and are inclined to repeatedly search for a suitable contact site on the mitochondrial membrane under nutrient starvation. Intermittent larger jumps are observed between clustered small steps during this process. Abstract: Dynamic membrane …
TME-responsive delivery nanosystems with rough surfaces (M-RMH) are proposed to enhance CO gas/immunotherapy through immune activation and immunosuppression regulation simultaneously. After the combination with aPD-L1-mediated checkpoint blockade therapy, robust antitumor immune responses are found to inhibit both primary and distant tumors. Abstract: Carbon monoxide (CO) gas therapy demonstrates great potential to induce cancer cell apoptosis …
Overexpression of the EGFR is found in up to 74% of bladder cancer (BCa) tissue. Two natural products that were found, triptolide (TPL) and hesperidin (HSP), could inhibit EGFR pathways. They are linked together into a prodrug that can form nanoparticles in a water environment, which not only remarkably improved their bioavailability and therapeutic but …
An ultrasensitive cathodic electrochemiluminescence immunoassay was developed by designing atomically Fe-anchored MOF-on-MOF nanozymes (CoNi-MOF@PCN-224/Fe) as ECL electrode materials and plasmonic Ag/AuNCs as high-efficient co-reactant quenchers. The proposed differential signal amplification strategy endowed the immunoassay with superior detection ability, which provide more possibilities for the ultrasensitive detection of disease markers in clinical diagnosis. Abstract: The successful …
