Research Article

Low photoconversion efficiency and limited tissue penetration are the major barriers for photothermal therapy (PTT) agent application. Here, an efficient organic/inorganic dual-PTT agent guided by MRI was proposed. It is proved the oxygen vacancy band narrowed its band gap that led to NIR-II region absorb. Furthermore, the defect energy level trapping carrier and conjugate synergistic …

Gd2O3/b-TiO2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy Read More »

Clinically approved indocyanine green (ICG) is utilized to develop simple prodrug nanoformulations. The ICG-driven assembly strategy endows paclitaxel prodrugs improved assembled behavior and enhanced colloidal stability, and the developed nanoparticles possess tumor-specific imaging and chemotherapy with in vivo therapeutic feedback. Abstract: Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. …

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy Read More »

This work describes a mild and efficient enzyme-catalyzed chemical reaction for the selective modification of Gram-positive bacterial cell walls. The as-designed technique can serve as a universal platform to functionalize the surfaces of live bacterial cells with diverse responsive materials, including small-molecule fluorescent dyes, horseradish peroxidase, and magnetic nanoparticles. Abstract: Chemically manipulating bacterial surface structures, …

Direct chemical editing of Gram-positive bacterial cell walls via an enzyme-catalyzed oxidative coupling reaction Read More »

A dynamic covalent polymeric antimicrobial, based on phenylboronic acid-installed micellar nanocarriers incorporating vancomycin and curcumin, was developed to overcome drug-resistant bacterial infections. Compared with monotherapy, this antimicrobial displayed more significant eradication of drug-resistant bacteria in vitro and in vivo. This work could become a universal platform to combat the ever-threatening drug-resistant infectious diseases. Abstract: Increasing …

A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection Read More »

Functional nucleic acid engineered double-barreled nanopores were designed and applied for measuring Na/K ratio (RNa/K) at single-cell level. The applicability of this nanotool is validated by practical probing intracellular RNa/K during the drug-induced primary stage of apoptotic volume decrease. Especially, the RNa/K has been shown by our nanotool to be different in cell lines with different metastatic …

Functional nucleic acid engineered double-barreled nanopores for measuring sodium to potassium ratio at single-cell level Read More »

Examining the phenotypes of KRAS mutant and wild-type colorectal cancer cells during anti-EGFR treatment may provide significant insights into drug resistance. Herein, we applied surface-enhanced Raman spectroscopy (SERS) assay to detect four cell surface proteins on KRAS mutant and wild-type cells over a 24-day treatment, where SERS assay achieved multiplexed characterization of cell surface markers …

SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment Read More »

We developed temozolomide and epigenetic bromodomain inhibitor co-encapsulated biomimetic nanomedicine (ABNM@TMZ/OTX) achieved multidimensional enhanced glioblastoma synergistic chemoimmunotherapy in both primary and recurrent orthotopic mice models with significant extended survival rate and little side effects. Abstract: Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid development of resistance to mono …

Brain co-delivery of first-line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy Read More »

Non-Hermitian physical principles are introduced into the design of on-chip photonic devices toward high robustness. As a proof-of-concept, an exclusive-or gate on silicon-on-insulator platform is designed by employing the exceptional point encirclement physics. The device performance is extremely robust to structural parameter disturbances, owing to the protection of the photon phase by the topological structure around …

Exceptional point protected robust on-chip optical logic gates Read More »

A new type of targeted chemogene is constructed through site-specific grafting camptothecins onto a phosphor othioate DNA containing antisense and aptamer segments. With simple and precise structure, the targeted chemogene shows hallmark properties in both in vitro and in vivo evaluations, including active targeting capability, vigorous gene regulation pitency, and prominent antiumor effect, providing new …

Drug-grafted DNA as a novel chemogene for targeted combinatorial cancer therapy Read More »

Currently, it is widely accepted that adsorption-energy scaling relations exist or not depending on the similarity of the adsorbates. Here, we show that CO and OH scale linearly or not on Pt alloys depending on the coordination of the adsorption sites. Hence, ligand and geometric effects can be used to modulate scaling relations, thereby opening …

Interplaying coordination and ligand effects to break or make adsorption-energy scaling relations Read More »