Research Article

Environment-friendly InP core/shell quantum dots (QDs) with quantum yield of ∼100% are prepared by aminophosphate precursors. The limit of detection of alpha-fetoprotein for in vitro diagnostics, specific labeling of liver cancer cells, and in vivo tumor-targeted imaging of live mice are comparable to that of the state-of-the-art Cd-QDs-based probes. Abstract: InP quantum dots (QDs) are …

Aminophosphate precursors for the synthesis of near-unity emitting InP quantum dots and their application in liver cancer diagnosis Read More »

It is challenging to develop new preparation methods of conductive polymer-based composite hydrogels for constructing all-in-one supercapacitors (A-SCs) with excellent deformation-tolerant performance. Self-wrinkled polyaniline-based composite hydrogels (SPCHs) with large stretchability and excellent fatigue resistance are fabricated by a stretching/cryopolymerization/releasing strategy. The as-obtained SPCH can work as an intrinsically stretchable A-SC maintaining high energy density and …

Cryopolymerization-enabled self-wrinkled polyaniline-based hydrogels for highly stretchable all-in-one supercapacitors Read More »

A forward osmosis and photothermal evaporation coupling system (FO-PE) based on high-performance polyamide FO membrane and photothermal polypyrrole nano-Sponge (PPy/Sponge) is developed for continuous FO separation with a steady water flux. The FO-PE coupling system utilizing clean and renewable solar energy to achieve efficient water treatment is significantly meaningful for practical applications. Abstract: Forward osmosis …

Coupling solar-driven interfacial evaporation with forward osmosis for continuous water treatment Read More »

Low photoconversion efficiency and limited tissue penetration are the major barriers for photothermal therapy (PTT) agent application. Here, an efficient organic/inorganic dual-PTT agent guided by MRI was proposed. It is proved the oxygen vacancy band narrowed its band gap that led to NIR-II region absorb. Furthermore, the defect energy level trapping carrier and conjugate synergistic …

Gd2O3/b-TiO2 composite nanoprobes with ultra-high photoconversion efficiency for MR image-guided NIR-II photothermal therapy Read More »

Clinically approved indocyanine green (ICG) is utilized to develop simple prodrug nanoformulations. The ICG-driven assembly strategy endows paclitaxel prodrugs improved assembled behavior and enhanced colloidal stability, and the developed nanoparticles possess tumor-specific imaging and chemotherapy with in vivo therapeutic feedback. Abstract: Self-assembled prodrug nanoparticles with tumor-responsive capacity have great potential in tumor visualization and treatment. …

Indocyanine green potentiated paclitaxel nanoprodrugs for imaging and chemotherapy Read More »

This work describes a mild and efficient enzyme-catalyzed chemical reaction for the selective modification of Gram-positive bacterial cell walls. The as-designed technique can serve as a universal platform to functionalize the surfaces of live bacterial cells with diverse responsive materials, including small-molecule fluorescent dyes, horseradish peroxidase, and magnetic nanoparticles. Abstract: Chemically manipulating bacterial surface structures, …

Direct chemical editing of Gram-positive bacterial cell walls via an enzyme-catalyzed oxidative coupling reaction Read More »

A dynamic covalent polymeric antimicrobial, based on phenylboronic acid-installed micellar nanocarriers incorporating vancomycin and curcumin, was developed to overcome drug-resistant bacterial infections. Compared with monotherapy, this antimicrobial displayed more significant eradication of drug-resistant bacteria in vitro and in vivo. This work could become a universal platform to combat the ever-threatening drug-resistant infectious diseases. Abstract: Increasing …

A dynamic covalent polymeric antimicrobial for conquering drug-resistant bacterial infection Read More »

Functional nucleic acid engineered double-barreled nanopores were designed and applied for measuring Na/K ratio (RNa/K) at single-cell level. The applicability of this nanotool is validated by practical probing intracellular RNa/K during the drug-induced primary stage of apoptotic volume decrease. Especially, the RNa/K has been shown by our nanotool to be different in cell lines with different metastatic …

Functional nucleic acid engineered double-barreled nanopores for measuring sodium to potassium ratio at single-cell level Read More »

Examining the phenotypes of KRAS mutant and wild-type colorectal cancer cells during anti-EGFR treatment may provide significant insights into drug resistance. Herein, we applied surface-enhanced Raman spectroscopy (SERS) assay to detect four cell surface proteins on KRAS mutant and wild-type cells over a 24-day treatment, where SERS assay achieved multiplexed characterization of cell surface markers …

SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment Read More »

We developed temozolomide and epigenetic bromodomain inhibitor co-encapsulated biomimetic nanomedicine (ABNM@TMZ/OTX) achieved multidimensional enhanced glioblastoma synergistic chemoimmunotherapy in both primary and recurrent orthotopic mice models with significant extended survival rate and little side effects. Abstract: Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid development of resistance to mono …

Brain co-delivery of first-line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy Read More »