Research Article

In this study, Zhang and colleagues show that drinking-water supplementation of D-mannose serves as an effective and potential therapeutic of type 2 diabetes, with improvement of both liver health and bone mass. The effect is exerted through suppressing macrophage release of extracellular vesicles based on metabolic control of CD36 expression. These findings shed light on …

D-Mannose Alleviates Type 2 Diabetes and Rescues Multi-Organ Deteriorations by Controlling Release of Pathological Extracellular Vesicles Read More »

Sustained nucleate boiling and Leidenfrost delay are critical for thermal and energy industries. Leveraging vapor buffer and reducing water-hammer pressure, this study realizes the enhancement of nucleate boiling and postponement of Leidenfrost by rationally designing and developing hierarchical nano–micro structured surfaces. Besides, AI technology is adopted to predict droplet boiling patterns on various structured surfaces. …

Sustained and Enhanced Nucleate Boiling Using Hierarchical Architectures at Large Superheats Read More »

Our findings suggest that miR-29a/b is a critical regulator of CD8+ T cells, possibly via the Ifng-JAK-STAT signal in IBD patients and the upregulation of miR-29a/b relieves the development of significant inflammation in the colon of DSS-induced colitis-affected mice. Abstract: The role of CD8+ T cells in the pathogenesis of ulcerative colitis (UC) remains unclear. Similarly, the posttranscriptional regulation of the …

MiR-29a/b Suppresses CD8+ T Cell Effector Function and Intestinal Inflammation Read More »

Long-term migration to high-altitude areas can readily result in chronic high-altitude diseases; however, effective prevention and treatment methods are currently lacking. This study employed a multi-omics approach, integrating metagenomics and metabolomics, to discover and validate that the decreased abundance of Veillonella rogosae, Streptococcus rubneri, and gut microbiota-associated serum metabolites, contributes to increased susceptibility to high-altitude heart abnormalities …

Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude: Gut Microbiota and Associated Metabolites Impart Heart Health in Plateau Read More »

Asiaticoside (AS) has known anti-inflammatory effects in diabetic wounds, but the underlying mechanisms are still unclear. In this study, we reveal that AS alleviates inflammation in diabetic wounds by activating ferroptosis of M1 macrophages, which is attributed to the downregulation of ferroportin 1 and ferritinophagy-induced degradation of ferritin heavy chain 1. Furthermore, AS was encapsulated …

Activating Ferroptosis of M1 Macrophages: A Novel Mechanism of Asiaticoside Encapsuled in GelMA for Anti-Inflammation in Diabetic Wounds Read More »

This study investigates the effect of protein properties on the nanomaterial-protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo-like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the BPNMs. Notably, BPNMs specifically bind to PLK1, while …

Target Binding of Black Phosphorus Nanomaterial to Polo-Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein Read More »

NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL-1β and TNF-α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation via the continuous activation of K375 site in …

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis: Modulating Crotonylation in Ulcerative Colitis Read More »

This study demonstrates that elevated N-acetyltransferase 10 (NAT10) expression stabilizes SMAD3 mRNA through ac4C modification, promoting the progression of hepatocellular carcinoma (HCC). NAT10 also activates the TGF-β signaling pathway, facilitating epithelial-to-mesenchymal transition and inhibiting anoikis. Furthermore, the authors develop a small-molecule inhibitor, NAT10-2023, which disrupts NAT10’s interaction with RNA, reducing ac4C modification levels and suppressing HCC …

Targeting NAT10 Inhibits Hepatocarcinogenesis via ac4C-Mediated SMAD3 mRNA Stability Read More »

To effectively alleviate the severe shuttle effect and delayed redox kinetics of lithium–sulfur batteries, CoWO4−x/CNT composites with different oxygen vacancy concentrations were prepared. The p–d orbital hybridization caused by oxygen vacancy enhances the bidirectional sulfur conversion, and provides valuable insights for the development of highly active catalysts for lithium–sulfur batteries. Abstract: Lithium–sulfur batteries (LSBs) have …

Enhancing Bidirectional Sulfur Conversion Through p–d Orbital Hybridization via Vacancy Engineering Read More »

The engineered bacteria (2’3′-cGAMP@E.coli) is designed to synthesize intracellular 2’3′-cGAMP, enabling the assembly of personalized nanovaccines (nECTs) through a bioconjugation with autologous tumor antigens, circumventing elaborate chemical production processes. The therapeutic impact of nECTs is significantly amplified when combined with a fasting-mimicking diet, illustrating the potent synergies of this integrated therapeutic approach. Abstract: Cyclic dinucleotides, …

Personalized Cancer Immunotherapy Boosted by cGAS-STING-Targeted Nanovaccines in Combination With Nutrient Modulation Read More »