Review Article

Bioactive inorganic particles-based biomaterials for skin tissue engineering

The inorganic biomaterials for wound healing have aroused widespread concern in the field of tissue engineering. The three main forms of application of inorganic particles for skin repair are summarized based on the complexity of material system. The representative types of inorganic biomaterials and fabrication technology of wound dressings are presented. Abstract: The challenge for …

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Advances in metal graphitic nanocapsules for biomedicine

In this review, we summary the preparation, classification, and properties of versatile metal graphitic nanocapsules, and then introduce the recent progress of their applications in biodetection, bioimaging, and therapy in detail. In addition, challenges and their development prospects in biomedicine are also discussed. We expect the metal graphitic nanocapsules will advance the development of future …

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Recent advances in overcoming barriers to cell-based delivery systems for cancer immunotherapy

This review covers the design of cell-based delivery systems for cancer immunotherapy, as well as the significant challenges limiting the efficacy of cell-based immunotherapy and summarizes recent advances in overcoming those barriers to improve cancer treatment outcomes. Abstract: Immunotherapy strategies that use cell-based delivery systems have sparked much interest in the treatment of malignancies, owing …

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Carrier strategies boost the application of CRISPR/Cas system in gene therapy

This review mainly focuses on the state-of-the-art CRISPR delivery systems and their applications, categorized by three types of cargo formats, that is, Cas: single-guide RNA ribonucleoprotein, Cas mRNA and single-guide RNA, and Cas plasmid expressing CRISPR/Cas systems. Abstract: Emerging clustered regularly interspaced short palindromic repeat/associated protein (CRISPR/Cas) genome editing technology shows great potential in gene …

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Strategies for enhancing cancer chemodynamic therapy performance

Chemodynamic therapy (CDT) utilizes endogenous H2O2 in tumor microenvironment to produce cytotoxic hydroxyl radicals through Fenton or Fenton-like reactions. This review outlines the fundamental understanding of Fenton and Fenton-like reactions and their relationship with CDT and highlights recent research advancements in the design of nanosystems to augment Fenton or Fenton-like reactions for enhanced CDT. Perspectives toward …

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Methodological advances of bioanalysis and biochemical targeting of intracellular G-quadruplexes

G-quadruplexes involve in various biological processes in living cells, and are considered as a promising new target for disease therapeutics, but the detailed mechanism of G4 biofunction remains elusive. This review highlights recent methodological advances about intracellular G-quadruplexes and provides an outlook on the improvement of the bioanalysis and biochemical targeting tools of G-quadruplexes. Abstract: …

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Harnessing anti-tumor and tumor-tropism functions of macrophages via nanotechnology for tumor immunotherapy

Modulating macrophages for tumor immunotherapy holds great promise to improve anti-tumor efficacy. Inhibition of macrophage recruitment, depleting tumor-associated macrophages (TAMs), repolarizing TAMs, and regulating macrophage-mediated phagocytosis of tumor cells are the four major strategies for manipulating macrophage-mediated tumor immunotherapy. Abstract: Reprogramming the immunosuppressive tumor microenvironment by modulating macrophages holds great promise in tumor immunotherapy. As …

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Rational design of allosteric switchable catalysts

Allosteric regulation controls the activities of natural enzymes and expands the chemical biology toolbox for the research on switchable catalysts. These rationally designed substitutes for unstable natural enzymes have been applied in areas such as biosensors and biomimetic cascade reactions. This review extended the concept of allosterism to artificial scaffolds and introduced a variety of …

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Organic fluorescent nanoprobes with NIR-IIb characteristics for deep learning

This paper reviews the recent progresses of organic fluorescent nanoprobes (OFNPs) with NIR-IIb emission, focusing on their construction strategies, optical properties, and their applications in deep learning in small animal models such as cerebrovascular imaging, tumor imaging, intestinal imaging, and systemic vascular imaging. In addition, the challenges and potential future research based on NIR-IIb fluorescent …

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Electrolyte formulation strategies for potassium-based batteries

This review mainly focuses on the recent progress of various liquid organic and solid-state K+¬†electrolytes for potassium-based batteries. First, the key design principles and applications of organic liquid electrolyte in various battery systems are discussed. Then the research status of ionic liquid, gel/polymer, and solid electrolyte are summarized and evaluated. Finally, this review discusses the …

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